Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study indicates that there is association between hyperglycaemia, oxidative stress (LPO), anti-oxidants (GSH, SOD and catalase), inflammatory cytokines, gut motility (OCTT), and small intestinal overgrowth in type 1 diabetes mellitus patients.
|
30155878 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg<sup>-1</sup>/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue.
|
30057670 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
The activities of serum superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were also estimated in diabetic patients infected with EV (T1D-EV+), those not infected with EV (T1D-EV-), and in nondiabetic controls.
|
29320773 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that polymorphisms of CAT and MnSOD may be associated with physiopathology causing the onset of T1D.
|
29859283 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association between the CAT gene SNP rs1001179 and T1D or DPN.
|
29924645 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Catalase activity, allelic variations in the catalase gene and risk of kidney complications in patients with type 1 diabetes.
|
24057136 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We measured glomerular structure and SF mRNA expression for catalase and glutathione peroxidase in 21 sibling pairs concordant for type 1 diabetes.
|
16877492 |
2006 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Major effects of two SNPs, rs769217" genes_norm="847">C1167T (rs769217) and C(-262)T (rs1001179), of the catalase gene on T1D susceptibility have been reported previously in Russians from Moscow.
|
16453382 |
2006 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes.
|
15111504 |
2004 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
This, therefore suggests that genes encoding catalase and other antioxidant enzymes may implicate in the development of type 1 diabetes.
|
15133753 |
2004 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of catalase (CAT), CuZn superoxide-dismutase (CuZnSOD), glutathione peroxidase (GPX), and Mn superoxide-dismutase (MnSOD) mRNA was quantified in peripheral blood mononuclear cells-obtained from 26 patients with type 1 diabetes and nephropathy, 15 with no microvascular complications after 20 years' duration of diabetes, and 10 normal healthy control subjects-that were exposed in vitro to hyperglycemia (HG) (31 mmol/l D-glucose).
|
12606529 |
2003 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The nucleotide substitutions in exon 4 in the patient with type 1 diabetes and that with fibrocalculous pancreatopathy occurred at codons 103 and 84 while that in exon 5 in the patient with type 1 diabetes occurred at codon 141, changing the codons from CAT to CAC, GTG to GCG, and ACT to AAT and resulting in H103H silent, V84A and T141N missense mutations, respectively.
|
11796176 |
2002 |
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
The delivery of transgenes capable of interfering with antigenic recognition and/or cell death [e.g., Fas ligand (FasL), Bcl-2, Bcl-XL] as well as imparting tolerance/immunoregulation [e.g., interleukin(IL)-4, IL-10, transforming growth factor (TGF)-beta], or cytoprotection [e.g., heme oxygenase-1 (HO-1), catalase, manganese superoxide dismutase (MnSOD)] may prevent recurrent type 1 diabetes in islet transplantation and offer a promising form of immunotherapy.
|
11899074 |
2001 |