|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg<sup>2+</sup> .
|
31793717 |
2020 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Taking advantage of the high catalytic efficiency of catalase when it meets hydrogen peroxide (H2O2), continuous oxygen can be generated due to the abnormally elevated level of H2O2 within the tumor, thus remarkably promoting tumor oxygenation.
|
31808470 |
2020 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
CAT was conjugated to the Momordica charantia-derived type-I ribosome-inactivating protein MAP 30, and the cytotoxicity of the MAP 30-CAT fusion protein in the tumor cell line SMMC-7721 was significantly enhanced compared with that of the unconjugated MAP 30.
|
31309656 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In such system, catalase acted as oxygen-self-supplier to catalyze the decomposition of tumor-abundant H<sub>2</sub>O<sub>2</sub> into O<sub>2</sub>, and the sustained release of RAP downregulated HIF-1α, which collectively potentiated the PDT efficacy against tumor.
|
31763809 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The formed PLGA-R837@Cat nanoparticles can greatly enhance radiotherapy efficacy by relieving the tumor hypoxia and modulating the immune-suppressive tumor microenvironment.
|
30663118 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Once released, GOx can rapidly deplete glucose and molecular oxygen in tumor cells while the toxic side product, <i>i.e.</i>, H<sub>2</sub>O<sub>2</sub>, can be readily decomposed by CAT for site-specific and low-toxicity tumor starvation.
|
31291092 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
EGCG-loaded PEVs and TEs exhibited an inhibitory effect on epidermoid carcinoma cell line (A431) in addition to reduced tumor sizes in mice, confirmed with histopathological analysis and biochemical quantification of skin oxidative stress biomarkers; glutathione, superoxide dismutase and catalase, as well as lipid peroxidation.
|
31252049 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The shell was modified with catalase (E), which catalyzes the conversion of hydrogen peroxide to oxygen at the tumor site, alleviating hypoxia and increasing the effect of the photodynamic treatment.
|
31534494 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The in vivo study was carried out for the evaluation of tumor incidence, pro-inflammatory cytokines such as TNF-α and IL-1α, lipid peroxidation values, glutathione content and catalase activity in mice.
|
30742987 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our <i>in vitro</i> data showed that Crt treatment significantly (<i>p</i> = 0.002) reduced the CAT activity in MCF-7, up to 24 h. The <i>in vivo</i> results showed that both Crt and Cro significantly increased the CAT activity in the tumor (<i>p</i> = 0.000 for both), and liver (<i>p</i> = 0.000 and <i>p</i> = 0.026 for Crt and Cro, respectively) tissues of 4T1-induced breast cancer in BALB/c mice, after 4 weeks of treatment.
|
31537178 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The aim of the present study was to evaluate the activity of antioxidant enzymes, such as superoxide dismutase (SOD; isoforms: Cu/ZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST), along with the concentration of malondialdehyde (MDA) in tumor and adjacent noncancerous tissues of two histological types of NSCLC, i.e., adenocarcinoma and squamous cell carcinoma, collected from 53 individuals with surgically resectable NSCLC.
|
31781331 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A key conclusion from these experiments is that tumor cell-generated RONS play the major role in inactivating protective catalase, depleting glutathione and establishing apoptosis-inducing RONS signaling.
|
31578342 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy.
|
30096565 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
After precision implantation of the ZCM nanocapsule into the tumor area under the real-time ultrasound (US) imaging guidance, the nanocapsule with 90% relative activity of equivalent free catalase enzyme efficiently modulates the tumor hypoxia and enhances the intratumoral US contrast by sustained decomposition of endogenous H2O2 and in situ production of O2 gas bubbles.
|
30198041 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Upon intravenous injection, HA@mpg-C<sub>3</sub>N<sub>4</sub>-HMME/CAT shows high tumor accumulation owing to the tumor-targeting HA coating.
|
29679806 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This work presents a simple yet effective strategy to promote tumor oxygenation via sequential delivering catalase and exogenous H<sub>2</sub>O<sub>2</sub> into tumors using well-established liposomal carriers, showing great potential for clinical translation in radio-immunotherapy of cancer.
|
30247918 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, the catalase-mimicking DNAzyme function of G-quadruplexes and hemin in those NCPs could decompose tumor endogenous H<sub>2</sub>O<sub>2</sub> to in situ generate oxygen so as to further enhance PDT by overcoming the hypoxia-associated resistance.
|
30303384 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Au@Pt nanoparticles as catalase mimics to attenuate tumor hypoxia and enhance immune cell-mediated cytotoxicity.
|
28925921 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Tumor cells, in contrast to non-malignant cells, show sustained expression of membrane-associated NADPH oxidase-1 and therefore generate extracellular superoxide anions and their dismutation product H<sub>2</sub>O<sub>2</sub> In order to prevent intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling, tumor cells need to express membrane-associated catalase that interferes with HOCl and nitric oxide/peroxynitrite signaling.
|
28179303 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Meanwhile, catalase within those nanoparticles could trigger decomposition of endogenic TME H<sub>2</sub>O<sub>2</sub> to generate oxygen in-situ so as to relieve tumor hypoxia.
|
27840167 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, higher levels of tumor MDA, Mn-SOD protein expression and urinary 8-epi-PGF2α were observed along with lower tumor CAT activity in poorly differentiated or undifferentiated (grade 3, G 3) versus well or moderately well differentiated (grade 1-2, G 1-2) serous EOC tumors.
|
28884887 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study aims to investigate the possible anticancer activity of two clinically used drugs: a natural antioxidant agent (salicin) and an antihyperlipidemic agent (fenofibrate) against two breast cancer models (in vivo EAC and in vitro MCF7) and the pancreatic cancer cell line (Panc-1).Our results have shown that both salicin and fenofibrate exerted an in vivo anticancer activity as evidenced by the decrease in tumor weight, tumor volume, CEA level, and reduced tumor cholesterol content through an antioxidant (reduced MDA level and increased GSH and catalase content) and an antiinflammatory activity (reduced TNF-∝ level).
|
28733879 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
NQO1: catalase levels (high in tumor, low in normal tissue) are an attractive therapeutic window to treat pancreatic cancer.
|
28346693 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Regarding intracellular antioxidant activity, a lower GPx activity in tumor cell lines and a higher catalase activity in MDA-MB-231 were observed.Thiol content was lower in MDA-MB-231.
|
27328417 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A strong local increase in the concentration of membrane-associated catalase is achieved during tumor progression and is controlled by tumor cell-derived H2O2 and by transglutaminase.
|
26140730 |
2015 |