Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas, and the role of these genes in neurogenesis suggests that they may contribute to development of glial tumors.
|
18940473 |
2008 |
Glioma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas, and the role of these genes in neurogenesis suggests that they may contribute to development of glial tumors.
|
18940473 |
2008 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme.
|
17504929 |
2007 |
Nervous System Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Chromogenic in situ hybridization showed gene amplification of LNX1 in 10%, Numbl in 5%, and KIT in 6% of nervous system tumors.
|
18940473 |
2008 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, the anti-breast cancer drug tamoxifen was found to be an agonist of LNX1 and suppress cancer stemness in CRC.
|
29190716 |
2017 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, the anti-breast cancer drug tamoxifen was found to be an agonist of LNX1 and suppress cancer stemness in CRC.
|
29190716 |
2017 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, the anti-breast cancer drug tamoxifen was found to be an agonist of LNX1 and suppress cancer stemness in CRC.
|
29190716 |
2017 |
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer.
|
30634502 |
2019 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer.
|
30634502 |
2019 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer.
|
30634502 |
2019 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, some reports show that Ligand of Numb Protein-X 1 (LNX1) could be a suppressor gene in gliomas, while our current research has firstly shown that PDZ domain containing ring finger 4 (PDZRN4), another member of LNX family, could also be a potential suppressor in hepatocellular carcinoma (HCC).
|
26486104 |
2015 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results collectively indicated that LNX1 contributed to tumor growth by inhibiting p53-dependent signaling in p53 wild-type cancer cells.-Park, R., Kim, H., Jang, M., Jo, D., Park, Y.-I., Namkoong, S., Lee, J. I., Jang, I.-S., Park, J. LNX1 contributes to tumor growth by down-regulating p53 stability.
|
31533005 |
2019 |
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These were rather focused and consistent with amplifications frequent in patient samples, involving the genes platelet-derived growth factor receptor A (PDGFRA), cysteine-rich hydrophobic domain 2 (CHIC2), FIP-like 1 (FIP1L1), ligand of numb-protein X1 (LNX1), RAS-like family 11 member B (RASL11B), and sec1 family domain containing 2 (SCFD2), probably a sign of continued tumor progression.
|
21713766 |
2012 |
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Through gene targeting we find that Lnx1 deficiency led to a hippocampal subregional disorder in neuronal activity and social memory impairments for partner discrimination observed in juvenile mice which also show cognitive defects in adult stage.
|
31772302 |
2019 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
|
30194396 |
2018 |
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
|
30194396 |
2018 |