|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In view of a polymorphism in the carnosinase 1 gene CNDP1, resulting in reduced carnosine degradation activity and a significant DN risk reduction, carnosine (β-alanyl-L-histidine) has gained attention as a potential therapeutic target.
|
30914013 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low serum carnosinase (CN-1) concentrations are associated with low risk for development of diabetic nephropathy (DN) in patients with type 2 diabetes (T2D).
|
29961141 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carnosinase 1 (CN1) has been postulated to be a susceptibility factor for developing diabetic nephropathy (DN).
|
29922921 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene CNDP1 was associated with the development of diabetic nephropathy.
|
31073745 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CNDP1 (CTG)<sub>5</sub> homozygous patients with T2D with DN had significantly lower CNDP1 concentrations (30.4 ± 18.3 vs 51.2 ± 17.6 µg/ml, p < 0.05) and activity (1.25 ± 0.5 vs 2.53 ± 1.1 µmol/ml/h, p < 0.05) than those without nephropathy.
|
30610469 |
2019 |
|
Diabetic Nephropathy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy.
|
28776438 |
2017 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the impact of the CNDP1 Mannheim allele on pediatric chronic kidney disease (CKD), we prospectively followed the long-term clinical outcome of 272 children with non-diabetic kidney disease (glomerulopathies n=32, non-glomerular kidney disease n=240).
|
27278783 |
2016 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Linkage of CTG trinucleotide (leucine) repeat polymorphism in CNDP1 gene with diabetic nephropathy has been observed in several populations.
|
27834323 |
2016 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for a 5-leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been associated with a reduced prevalence of diabetic nephropathy in cross-sectional studies in patients with type 2 diabetes, particularly in women.
|
24756973 |
2015 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carnosinase 1 (CN1) contributes to diabetic nephropathy by cleaving histidine-dipeptides which scavenge reactive oxygen and carbonyl species and increase nitric oxide (NO) production.
|
26081982 |
2015 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors conducted meta-analysis on association between the CNDP1 D18S880 microsatellite polymorphism and DN susceptibility, using fixed and random effects models.
|
23402577 |
2013 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the association of polymorphisms within the CNDP1/CNDP 2 locus with diabetic nephropathy in Japanese subjects with type 2 diabetes.
|
23342076 |
2013 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data may further clarify the link among CNDP1 genotype, carnosinase, and diabetic nephropathy.
|
22496410 |
2012 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we identified an allelic variant of human carnosinase 1 (CN1) that results in increased enzyme activity and is associated with susceptibility for diabetic nephropathy in humans.
|
21833769 |
2012 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
CTD_human |
Two SNPs, rs2346061 in CNDP1 and rs7577 in CNDP2, were associated with an increased risk of diabetic nephropathy (rs2346061 p = 5.07 × 10(-4); rs7577 p = 0.021).
|
21573905 |
2011 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease.
|
21393041 |
2011 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, rs2346061 in CNDP1 and rs7577 in CNDP2, were associated with an increased risk of diabetic nephropathy (rs2346061 p = 5.07 × 10(-4); rs7577 p = 0.021).
|
21573905 |
2011 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
CTD_human |
These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease.
|
21393041 |
2011 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CNDP1 polymorphism was not associated with mortality, and nor was there an interaction of this polymorphism with DN for prediction of mortality in patients with type 1 diabetes.
|
20711718 |
2010 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans.
|
20299368 |
2010 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study suggests that the association between the CNDP1 gene and diabetic nephropathy is sex specific and independent of susceptibility for type 2 diabetes.
|
20332346 |
2010 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands.
|
19577318 |
2009 |
|
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Protection from diabetic nephropathy afforded by 5L-5L homozygosity in CNDP1 may be masked by the effects of additional risk haplotypes in CNDP1 and CNDP2.
|
19373489 |
2009 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes.
|
18753673 |
2008 |
|
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes.
|
18753673 |
2008 |