ZNF503, zinc finger protein 503, 84858

N. diseases: 11; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Our findings indicate that miR-340-5p inhibits NCI-H1650 cell proliferation and invasion by directly targeting ZNF503 and that miR-340-5p can serve as a potential therapeutic target for treating NSCLC. 31160893 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Clinical data showed that high ZNF503 was significantly correlated with poor prognostic features, including advanced TNM stage and venous invasion. 31312355 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE ZNF503 drives tumor development and process and was cancer-specific dysregulated in cancers. 31312355 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE Our findings indicate that miR-340-5p inhibits NCI-H1650 cell proliferation and invasion by directly targeting ZNF503 and that miR-340-5p can serve as a potential therapeutic target for treating NSCLC. 31160893 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE ZNF503 drives tumor development and process and was cancer-specific dysregulated in cancers. 31312355 2019
CUI: C0332915
Disease: Congenital failure of fusion
Congenital failure of fusion 		0.010 AlteredExpression disease BEFREE Upregulation of Nlz2 in zebrafish embryos resulted in downregulation of <i>pax2a</i> expression and fissure fusion failure. 31189662 2019
CUI: C0598935
Disease: Tumor Initiation
Tumor Initiation 		0.010 Biomarker phenotype BEFREE Zinc finger protein ZNF503 is an important regulator during developmental process and tumor initiation. 31312355 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE ZNF503 drives tumor development and process and was cancer-specific dysregulated in cancers. 31312355 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 Biomarker disease BEFREE Moreover, ZNF503 was identified as a potential 5-year prognostic marker of HCC patients. 31312355 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of <i>GATA3</i> expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. 28258171 2017
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.010 Biomarker disease BEFREE Finally, lncRNA based prognosis index (PI) could predict overall survival of LUSC with high accuracy (AUC = 0.652, CI: 0.598, 0.705), PI = exp<sub>CYP4F26P</sub>*β<sub>CYP4F26P</sub>+exp<sub>RP11-108M12.3</sub>*β<sub>RP11-108M12.3</sub>+exp<sub>RP11-38M8.1</sub>*β<sub>RP11-38M8.1</sub>+exp<sub>RP11-54H7.4</sub>*β<sub>RP11-54H7.4</sub>+exp<sub>ZNF503-AS1</sub>*β<sub>ZNF503-AS1</sub>. 28881601 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of <i>GATA3</i> expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. 28258171 2017