|
Ventricular Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
The CHB that is a major challenge for closure of VSDs is less common with soft, specially designed ADO II, which does not compress the conducting system.
|
24130123 |
2017 |
|
Complete atrioventricular block
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Use of the ADO II in non-ductal positions can be achieved with high success and low complication rates, especially CHB; its use is also associated with significantly reduced procedure time and device cost.
|
24130123 |
2017 |
|
Aorta to right ventricle tunnel
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Out of 79 defects closed with ADO II, 61 had perimembranous, 12 apical/mid-muscular ventricular septal defects (VSD), 4 Gerbode defects, one each of coronary arterio-venous fistula and aorto-right ventricular tunnel.
|
24130123 |
2017 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we have predicted a 3D model structure for ADO and summarized the biological roles and the pathological consequences which are associated with the altered expression and functioning of ADO and CDO in case of cancer, neurodegenerative disorders and other human diseases.
|
28439920 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we have predicted a 3D model structure for ADO and summarized the biological roles and the pathological consequences which are associated with the altered expression and functioning of ADO and CDO in case of cancer, neurodegenerative disorders and other human diseases.
|
28439920 |
2017 |
|
Pulmonary arterial hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report interventional re-opening of a PDA for reverse Potts shunt circulation 12 months after closure in a 3.8 year old child, suffering from right ventricular (RV) failure due to suprasystemic pulmonary artery hypertension (PAH) after ADO I implantation.
|
27516058 |
2017 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
We report interventional re-opening of a PDA for reverse Potts shunt circulation 12 months after closure in a 3.8 year old child, suffering from right ventricular (RV) failure due to suprasystemic pulmonary artery hypertension (PAH) after ADO I implantation.
|
27516058 |
2017 |
|
Bronchial artery aneurysm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among the 114 patients submitted to ADO II-AS implantation at our institution, 12 received this device as off-label treatment of paravalvular leak (n = 5), sinus of Valsalva fissuration (n = 2), accessory atrial septal defect (n = 2), muscular ventricular septal defect (n = 1), bleeding bronchial artery aneurysm (n = 1) and reverse shunt due to abnormal origin of left subclavian artery from pulmonary artery (n = 1).
|
27898501 |
2017 |
|
Osteosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autosomal dominant osteopetrosis type II (ADO-II) is a heritable bone disorder characterized by osteosclerosis, predominantly involving the spine (vertebral end-plate thickening, or rugger-jersey spine), the pelvis ("bone-within-bone" structures) and the skull base.
|
26056022 |
2016 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression.
|
27911956 |
2016 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
There was weaker evidence for iCHAV4, located 5' of ADO, associated only with ER-positive breast cancer (OR = 0.93 [0.90-0.96]).
|
26073781 |
2015 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Given the central role of intestinal epithelial cells to the development of colitis, we hypothesized that specific Ado receptors would contribute to disease resolution in mucosal inflammation as modeled by dextran sodium sulfate (DSS) colitis.
|
19342675 |
2009 |
|
Carney Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to study the antiproliferative effects of 8-Cl-ADO on growth and proliferation in B-lymphocytes of Carney complex patients that have PKA defects and to determine whether 8-CL-ADO could be used as a therapeutic agent in the treatment of Carney complex-associated tumors.
|
19773399 |
2009 |
|
Familial (FPAH)
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study provided information on the pattern of radiological features in familial asymptomatic ADO II.
|
19547970 |
2009 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations may have important implications for therapeutic strategies targeting Ado receptors in the setting of MI.
|
18653544 |
2008 |
|
Severe Combined Immunodeficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the basis for immunosuppression by Ado has not been well defined, and effects of 2'-deoxyadenosine (dAdo), which does not activate Ado receptors, have also been implicated in causing SCID.
|
15580654 |
2005 |