|
Obesity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Perturbation of eight out of the nine genes, with Gas7, Me1 and Gpx3 being newly confirmed, resulted in significant changes in obesity-related traits.
|
19270708 |
2009 |
|
Glaucoma, Primary Open Angle
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to investigate the association between the polymorphism rs11656696 located in the growth arrest-specific 7 gene (<i>GAS7</i>) and POAG.
|
31269845 |
2019 |
|
Glaucoma, Primary Open Angle
|
0.070 |
Biomarker
|
disease |
BEFREE |
The association between SNPs near GAS7 and POAG was found in Japanese patients for the first time.
|
29261660 |
2017 |
|
Glaucoma, Primary Open Angle
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism rs11656696 in GAS7 Is Not Associated with Primary Open Angle Glaucoma in a Saudi Cohort.
|
29022762 |
2017 |
|
Glaucoma, Primary Open Angle
|
0.070 |
Biomarker
|
disease |
BEFREE |
To investigate the association between the additive effects of genetic variants associated with intraocular pressure (IOP) and IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of primary open-angle glaucoma (POAG), and to evaluate the clinical usefulness of the additive effects of IOP-related genetic variants for predicting IOP elevation, Japanese patients with HTG (n = 255) and NTG (n = 261) and 246 control subjects were genotyped for nine IOP-related genetic variants near CAV2, GAS7, GLCCI1/ICA1, ABCA1, ARHGEF12, FAM125B, FNDC3B, ABO, and PTPRJ/AGBL2.
|
28832686 |
2017 |
|
Glaucoma, Primary Open Angle
|
0.070 |
Biomarker
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
|
26690118 |
2015 |
|
Glaucoma, Primary Open Angle
|
0.070 |
Biomarker
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-angle glaucoma (POAG) at CDKN2B-AS1, CAV1/CAV2, and SIX1/SIX6.
|
24002674 |
2014 |
|
Glaucoma, Primary Open Angle
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We successfully replicated the associations with GAS7 (P = 7.4 × 10(-3)) for IOP, and also identified a previously reported POAG locus in the CAV1/CAV2 region to be associated with IOP (P = 3.3 × 10(-3)).
|
25525164 |
2014 |
|
Intraocular pressure disorder
|
0.040 |
Biomarker
|
disease |
BEFREE |
To investigate the association between the additive effects of genetic variants associated with intraocular pressure (IOP) and IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of primary open-angle glaucoma (POAG), and to evaluate the clinical usefulness of the additive effects of IOP-related genetic variants for predicting IOP elevation, Japanese patients with HTG (n = 255) and NTG (n = 261) and 246 control subjects were genotyped for nine IOP-related genetic variants near CAV2, GAS7, GLCCI1/ICA1, ABCA1, ARHGEF12, FAM125B, FNDC3B, ABO, and PTPRJ/AGBL2.
|
28832686 |
2017 |
|
Intraocular pressure disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
More recently, genome-wide association studies (GWAS) have shown that common genetic variants in the GAS7 and TMCO1 genomic regions are associated with elevated IOP.
|
24138038 |
2014 |
|
Intraocular pressure disorder
|
0.040 |
Biomarker
|
disease |
BEFREE |
We successfully replicated the associations with GAS7 (P = 7.4 × 10(-3)) for IOP, and also identified a previously reported POAG locus in the CAV1/CAV2 region to be associated with IOP (P = 3.3 × 10(-3)).
|
25525164 |
2014 |
|
Intraocular pressure disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-angle glaucoma (POAG) at CDKN2B-AS1, CAV1/CAV2, and SIX1/SIX6.
|
24002674 |
2014 |
|
Schizophrenia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth arrest specific 7 (Gas7) protein is a cytoskeleton regulator playing a crucial role in neural cell development and function, and has been implicated in Alzheimer disease, schizophrenia and cancers.
|
31296381 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The growth arrest-specific gene 7 (GAS7), a member of the growth-arrest-specific family, encodes three protein isoforms (GAS7A, GAS7B, and GAS7C) and plays a potential role in lung cancer as a tumor suppressor gene.
|
28475688 |
2017 |
|
Schizophrenia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In our research, we identified growth arrest specific gene 7 (GAS7) as a schizophrenia risk gene in two independent Han Chinese populations using a two-stage association study.
|
27189492 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Fifty CpG sites located within CpG islands-in genes ATXN7L1 (2), BMP3 (7), EID3 (15), GAS7 (1), GPR75 (24), and TNFAIP2 (1)-were significantly hypermethylated in tumor vs. normal tissues (P<0.05).
|
24441198 |
2014 |
|
Treatment related acute myeloid leukaemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML).
|
16956839 |
2006 |
|
leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice.
|
12620410 |
2003 |
|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
|
10706619 |
2000 |
|
Treatment related acute myeloid leukaemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
GAS7 is a new partner gene of MLL in treatment-related acute myeloid leukemia.
|
10706619 |
2000 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Growth arrest specific 7 (Gas7) protein is a cytoskeleton regulator playing a crucial role in neural cell development and function, and has been implicated in Alzheimer disease, schizophrenia and cancers.
|
31296381 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways.
|
29706651 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and β1-integrin/FAK/Src signaling.
|
29706651 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways.
|
29706651 |
2018 |
|
Low Tension Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the association between the additive effects of genetic variants associated with intraocular pressure (IOP) and IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of primary open-angle glaucoma (POAG), and to evaluate the clinical usefulness of the additive effects of IOP-related genetic variants for predicting IOP elevation, Japanese patients with HTG (n = 255) and NTG (n = 261) and 246 control subjects were genotyped for nine IOP-related genetic variants near CAV2, GAS7, GLCCI1/ICA1, ABCA1, ARHGEF12, FAM125B, FNDC3B, ABO, and PTPRJ/AGBL2.
|
28832686 |
2017 |