|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In vitro assays revealed that only the kidney disease-associated ApoL1 variants lysed Trypanosoma brucei rhodesiense.
|
20647424 |
2010 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Statistically stronger associations were detected between two independent sequence variants in the Apolipoprotein L1 gene (APOL1) and nondiabetic nephropathy in African Americans, with odds ratios of 10.5 in idiopathic FSGS and 7.3 in hypertension-attributed ESRD.
|
20688934 |
2010 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
MYH9 and APOL1 are both associated with sickle cell disease nephropathy.
|
21910715 |
2011 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The linkage peak on chromosome 22q overlaps the MYH9/APOL1 gene region, previously implicated in AA diabetic and nondiabetic nephropathies.
|
21454968 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We determined the frequency of the APOL1 G1 and G2 risk variants together with the prevalence of HIV-associated nephropathy (HIVAN) among individuals of Ethiopian ancestry to determine whether the kidney disease genetic risk is PanAfrican or restricted to West Africa, and can explain the previously reported low risk of HIVAN among Ethiopians.
|
21968148 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Twenty-two of 136 transplanted kidneys (16%) were from donors with two APOL1 nephropathy risk variants.
|
21486385 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this replication study, we examined the six top-most associated variants in APOL1 and MYH9 in an independent cohort of African Americans with various nephropathies (44 with FSGS, 21 with HIVAN, 32 with IgA nephropathy, and 74 healthy controls).
|
21997397 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOL1 variants and kidney disease. There is no such thing as a free lunch.
|
21216884 |
2011 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Comparing the renal distribution of APOL1 in nondiabetic kidney disease to normal kidney suggests that a previously unrecognized arteriopathy may contribute to disease pathogenesis in patients of African ancestry.
|
21997392 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The numbers with 2, 1 and 0 APOL1 nephropathy risk variants, respectively, were 36, 17 and 20.
|
21931123 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown.
|
21997394 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Two variants in the APOL1 gene, to date observed only among individuals of recent African ancestry, associate with increased risk for renal disease among African Americans.
|
21997398 |
2011 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we tested these risk variants in the Dallas Heart Study to ascertain the prevalence of APOL1-associated renal disease in a large population-based study and to estimate the contribution of APOL1 risk variants to disparities in renal disease.
|
21997396 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The powerful evolutionary selection pressure of an infectious pathogen in West Africa favored the spread of APOL1 variants that protect against a lethal form of African sleeping sickness but are highly associated with an increased risk of kidney disease.
|
21537348 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here, we examined the role of APOL1 risk variants in predicting renal histopathology and progression to ESRD in 98 HIV-infected African Americans with non-HIVAN kidney disease on biopsy.
|
22135313 |
2012 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Second hits appear necessary for the initiation of APOL1-associated nephropathy.
|
22695330 |
2012 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Discovery of APOL1-associated nephropathy was a major success of the genetics revolution, demonstrating that secondary hypertension is typically present in nondiabetic African Americans with nephropathy.
|
22068337 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOL1 G1/G2 nephropathy risk variants were rare in individuals of European American heritage, present in 0.28% of chromosomes in T2DM-ESRD cases and 0.32% of controls.
|
21968013 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hence, APOL1 mutations produce a distinct category of kidney disease that manifests at younger ages in African ancestry populations.
|
22357707 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among African-Americans, genome wide association revealed a strong correlation between the G1 and G2 alleles of APOL1 (apolipoproteinL1, also called trypanolytic factor) and kidney diseases including focal and segmental glomerulosclerosis, HIV-associated nephropathy and hypertensive nephrosclerosis.
|
23300552 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This follow-up of a pooled GWAS provides additional and independent evidence that APOL1 variants contribute to nondiabetic nephropathy in African Americans and identified additional associated and interactive nondiabetic nephropathy susceptibility genes.
|
22119407 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, an association was found between nondiabetic kidney disease in African Americans and two independent sequence variants in the APOL1 gene, encoding apolipoprotein L1.
|
22495294 |
2012 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mapping by admixture linkage disequilibrium (MALD; or admixture mapping) recently led to a major breakthrough in hypertension-attributed kidney disease in African Americans, demonstrating the role of the apolipoprotein L1 (APOL1) and nonmuscle myosin heavy chain 9 (MYH9) genes in this primary kidney disease residing in the spectrum of focal segmental glomerulosclerosis.
|
22614628 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent work suggests that the high risk for all of these forms of kidney disease in African Americans is conferred by the same genetic risk factors, specifically two coding sequence variants in the APOL1 gene.
|
22257798 |
2012 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes.
|
22189356 |
2012 |