|
Acute angle-closure glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CLR transgenic mice used in the present study provide a model for acute angle-closure glaucoma.
|
17608625 |
2008 |
|
Adenocarcinoma of large intestine
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adult Pilocytic Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Real-time quantitative RT-PCR showed expression of RAMP2, RAMP3 and CLR in PA and GBM, suggesting that AM may function as an autocrine/paracrine growth factor for GBM cells.
|
21458987 |
2011 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we found that a 50% reduction of CLR, the G-protein receptor component of the CGRP receptor, also ameliorated airway resistance and inflammation in this model of allergic asthma.
|
25010197 |
2014 |
|
Angle Closure Glaucoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, in humans, defective regulation of adrenomedullin action in the pupillary sphincter muscle, provoked in the present study in CLR transgenic mice, may cause acute and chronic atony and, thereby, contribute to the development of angle-closure glaucoma.
|
17608625 |
2008 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown.
|
30867470 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, since RAMP-receptor interfaces are pharmacologically tractable, it may be possible to develop compounds targeting the RAMP1/CLR interface to assist in the treatment of asthma.
|
25010197 |
2014 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown.
|
30867470 |
2019 |
|
Carcinomatosis of peritoneal cavity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we show that a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6'-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development in a mouse model of aggressive mammary cancer-induced peritoneal carcinomatosis.
|
30224373 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis.
|
28904253 |
2017 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we showed that the development of cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) in Uighur women was accompanied with the partial or total loss of protein expression of HLA-I, ß2-m and APM components, including the transporter associated with antigen processing (TAP1/2), low molecular mass protein (LMP2, LMP7), endoplasmic reticulum aminopeptidase 1(ERAP1), chaperone molecules include calreticulin (CLR), calnexin (CNX) and ERp57, and this was proved again by analysis of transcription of the same genes in addition to three genes HLA-A, B and C coding for HLA-I.
|
23024775 |
2012 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we showed that the development of cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) in Uighur women was accompanied with the partial or total loss of protein expression of HLA-I, ß2-m and APM components, including the transporter associated with antigen processing (TAP1/2), low molecular mass protein (LMP2, LMP7), endoplasmic reticulum aminopeptidase 1(ERAP1), chaperone molecules include calreticulin (CLR), calnexin (CNX) and ERp57, and this was proved again by analysis of transcription of the same genes in addition to three genes HLA-A, B and C coding for HLA-I.
|
23024775 |
2012 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Childhood Pilocytic Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Real-time quantitative RT-PCR showed expression of RAMP2, RAMP3 and CLR in PA and GBM, suggesting that AM may function as an autocrine/paracrine growth factor for GBM cells.
|
21458987 |
2011 |
|
Chronic acquired lymphedema
|
0.010 |
Biomarker
|
disease |
BEFREE |
AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated in angiogenesis and lymphangiogenesis during embryogenesis and wound healing, suggesting their possible involvement in secondary lymphedema.
|
23364478 |
2013 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Our findings reveal previously unrecognized CLR upregulation in an autocrine loop with adrenomedullin in RCC with potential application for this GPCR as a target for future functional studies and drug development.
|
23969937 |
2013 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the present findings suggest that synovial macrophages are the major producers of IL-1β and regulators of CLR in OA mice.
|
26400621 |
2016 |
|
Ewings sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study it has been shown that the reactive nitrogen species, peroxynitrite, can cause at least a 7.1-fold increase in the frequency of occurrence of drug-resistant mutants of Helicobacter pylori at a pathophysiological concentration (e.g.1.0 microM) and in the presence of CLR.
|
19161551 |
2009 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
DCLK3 also produced beneficial effects on motor symptoms in a knock-in mouse model of Huntington's disease.
|
29534157 |
2018 |
|
Immune System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Several CLR genes have been genetically linked to susceptibility to immunologic disorders.
|
15771576 |
2005 |
|
Infiltrating duct carcinoma of female breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Large cell carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|