|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This expansion of the LGR5 compartment coincides with maintenance of crypt-like glandular structure (adenomas, and well and moderately differentiated adenocarcinomas), and is reduced in poorly differentiated CRC, where crypt-like glandular architecture is lost, accompanied by reduced epithelial terminal differentiation.
|
28958617 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, we found correlations between LGR5 and CRC-specific genes, including dickkopf WNT signaling pathway inhibitor 4 (<i>DKK4</i>) and SPARC-related modular calcium binding 2 (<i>SMOC2</i>).
|
29467240 |
2018 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Positive correlations were observed between the expression of LGR5 and cytoplasmic GATA6 in adenoma (P=0.0005; r<sub>s</sub>=0.48) and adenocarcinoma samples (P=0.007; r<sub>s</sub>=0.38): However, no significant association was observed in normal mucosa (P=0.399).
|
29434936 |
2018 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Enhanced LGR5 expression remained persistent during the adenoma-carcinoma transition, but markedly declined in the budding cancer cells at the invasive fronts, which was not due to altered wingless-type mouse mammary tumor virus integration site family (Wnt) or epithelial-mesenchymal transition signaling.
|
30036518 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The well characterised deregulation of Wnt/β-catenin signalling that occurs during the adenoma-carcinoma sequence in colorectal cancer (CRC) renders LGR5 an interesting therapeutic target.
|
29844449 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Counting results showed that the grading scores of cells positive for LGR5 and ALDH1 in the adenoma/CRC epithelium were significantly increased relative with the control epithelium, and associated with the degree of dysplasia in the adenoma and node involvement in the CRC (all P < 0.05).
|
28484082 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we showed, using the multicolor lineage-tracing method and mouse models of intestinal adenocarcinoma and adenoma that Bmi1- or Lgr5- positive tumorigenic cells clonally expanded in proliferating tumors.
|
28176811 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously showed that mutation of RZ in the intestine yields rapidly growing adenomas containing LGR5(+) (leucine-rich repeat-containing G-protein coupled receptor 5) stem cells and Wnt3-producing Paneth cells.
|
26023187 |
2015 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We used mouse and human ex vivo 3D intestinal organoid cultures and in vivo mouse models to study the effect of TGF-β on the Lgr5(+) intestinal stem cells and their progeny in intestinal adenomas.
|
24825889 |
2014 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, LGR5 small interfering RNA inhibited the survival-promoting effects of PGE2 in RG/C2, suggesting that PGE2 promotes adenoma cell survival, at least in part, by increasing LGR5 expression.
|
23349017 |
2013 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise.
|
22637696 |
2013 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5+ stem cells.
|
22895187 |
2012 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In clinical specimens, there was significant overexpression of LGR5 in 35 of 50 colorectal cancers (CRCs), and in seven of seven sporadic colonic adenomas, compared with matched normal mucosa.
|
20384634 |
2010 |