|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Additionally, a higher tumoral level of LGR5Δ5 mRNA in primary tumors was associated with the occurrence of regional lymph node metastases in OSCC patients (odds ratio (OR) = 3.1; p = 0.022; 95% CI: 1.2-7.9; binary logistic regression).
|
30770730 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Multivariable analysis confirmed that negative LGR5 expression was an independent risk factor for peritoneal recurrence (hazard ratio (HR) 2.79, p = 0.005) in addition to poor differentiation, positive lymph node metastasis, preoperative carcinoembryonic antigen > 5 ng/mL and anastomotic leakage.
|
31000786 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Lgr5 expression was significantly correlated with lymph node metastasis, increased depth of invasion, increased tumor size, advanced differentiation, higher AJCC stage and poorer survival.
|
28404917 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that high expression of Lgr5 was not associated to the depth of tumor invasion (pooled OR=1.395, CI95%=0.652-2.958, P=0.392, random-effect), gender of patients (pooled OR=1.264, 95%CI=0.933-1.713, P=0.13, fixed effect), tumor distance metastasis (pooled OR=1.1, 95%CI=0.734-3.754, P=0.772, random-effect), tumor size (pooled OR=0.977, 95%CI=0.705-1.353, P=0.887, random-effect), TNM stages (pooled OR=1.304, 95%CI=0.449-3.789, p=0.625, random-effect) and lymph node metastasis (pooled OR=1.507, 95%CI=0.829-2.738, P=0.178, random-effect).
|
26077638 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
Biomarker
|
disease |
BEFREE |
As a biomarker, LGR5 positivity predicts lymph node metastasis with 95.5% sensitivity (95% CI 88.8%-98.7%) and 61% specificity (95% CI: 48.4%-72.4%) and has a negative predictive value (NPV) of 91.3% (95% CI 79.2%-97.5%) for lymph node metastatic disease.
|
26416247 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Lgr5 mRNA expression level in tissue with lymph node metastasis was significantly higher than that in the tissue without lymph node metastasis, and the difference was statistically significant (P < 0.05).
|
27352328 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Low and high expression levels of Lgr5 were significantly correlated with clinicopathological features such as TNM stage, lymph node metastasis and vascular invasion of CRC patients.
|
24751002 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
High Lgr5 expression was significantly correlated with lymph node metastasis (p = 0.003), late stage (p = 0.003) and unfavorable response to chemotherapy (p = 0.013) according to RECIST 1.0 criteria.
|
24666414 |
2014 |