|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells.
|
24899388 |
2014 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells.
|
24899388 |
2014 |
|
Heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Dysregulation of Mfn2 and Drp-1 proteins in heart failure.
|
24905188 |
2014 |
|
Congestive heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Dysregulation of Mfn2 and Drp-1 proteins in heart failure.
|
24905188 |
2014 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we show that mitochondrial division inhibitor-1 (mdivi-1), an inhibitor of dynamin-related protein1 (Drp1), modulates mitochondrial morphology and TRAIL-induced apoptosis in human cancer cells. mdivi-1 treatment (≥12.5 µM) caused dose- and time‑dependent cell death in malignant melanoma, lung cancer and osteosarcoma cells, while sparing normal cells. mdivi-1 also sensitized cancer cells to TRAIL-induced apoptosis.
|
25174275 |
2014 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, targeting Drp1-dependent mitochondrial dynamics may provide a novel strategy to suppress breast cancer metastasis and improve the chemotherapeutic effect in the future.
|
25434519 |
2015 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, targeting Drp1-dependent mitochondrial dynamics may provide a novel strategy to suppress breast cancer metastasis and improve the chemotherapeutic effect in the future.
|
25434519 |
2015 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Thus, targeting Drp1-dependent mitochondrial dynamics may provide a novel strategy to suppress breast cancer metastasis and improve the chemotherapeutic effect in the future.
|
25434519 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo findings confirmed that erucin-mediated inhibition of tumor growth in a breast cancer cell xenograft mouse model is associated with the mitochondrial translocation of cofilin and Drp1, fission and apoptosis.
|
25595902 |
2015 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
In vivo findings confirmed that erucin-mediated inhibition of tumor growth in a breast cancer cell xenograft mouse model is associated with the mitochondrial translocation of cofilin and Drp1, fission and apoptosis.
|
25595902 |
2015 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In vivo findings confirmed that erucin-mediated inhibition of tumor growth in a breast cancer cell xenograft mouse model is associated with the mitochondrial translocation of cofilin and Drp1, fission and apoptosis.
|
25595902 |
2015 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
|
25658205 |
2015 |
|
Pancreatic carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phosphorylation and mitochondrial fragmentation are increased in human pancreatic cancer.
|
25658205 |
2015 |
|
Malignant neoplasm of pancreas
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phosphorylation and mitochondrial fragmentation are increased in human pancreatic cancer.
|
25658205 |
2015 |
|
Diabetic Nephropathy
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data suggest that PGC-1α may protect DN via the inhibition of DRP1-mediated mitochondrial dynamic remodeling and ROS production.
|
25853493 |
2015 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission.
|
26119034 |
2015 |
|
Endothelial dysfunction
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction.
|
26196303 |
2015 |
|
Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
|
26247724 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well.
|
26356820 |
2015 |
|
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
|
26518267 |
2015 |
|
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
|
26518267 |
2015 |
|
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
|
26518267 |
2015 |
|
Heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Haploinsufficiency of Drp1 abolished mitochondrial autophagy and exacerbated the development of both mitochondrial dysfunction and heart failure after TAC.
|
26915633 |
2016 |
|
Congestive heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Haploinsufficiency of Drp1 abolished mitochondrial autophagy and exacerbated the development of both mitochondrial dysfunction and heart failure after TAC.
|
26915633 |
2016 |
|
Glioma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR.
|
27171399 |
2016 |