|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The Autoimmune Disorder Susceptibility Gene <i>CLEC16A</i> Restrains NK Cell Function in YTS NK Cell Line and <i>Clec16a</i> Knockout Mice.
|
30774629 |
2019 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, the expression levels of the genes including ACLY, ALDH18A1, HADHA, and YARS in the PBMCs tissue and HBEGF, PKN3, DEGS2, and EDN3 in the fat tissue were found to be different in the HIV-infected patients, which can be considered as new biomarkers for HIV infection.
|
31317550 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results show that ectopic expression of TCR α/β chains, along with CD3 subunits, enables the functional expression of an antigen-specific TCR complex on NK cell lines NK-92 and YTS, demonstrated by using a TCR against the HLA-A2-restricted tyrosinase-derived melanoma epitope, Tyr<sub>368-377</sub> .
|
31054264 |
2019 |
|
Squamous cell carcinoma of mouth
|
0.010 |
Biomarker
|
disease |
BEFREE |
The elevated levels of 4 proteins (IARS, KARS, WARS, and YARS) involved in the aminoacyl tRNA biosynthesis were verified in the OSCC tissues with immunohistochemistry (IHC).
|
31315917 |
2019 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, such impairment of cytolytic activity of asthma -associated YTS NK cells was accompanied with aberrantly enriched genes involved in oxidative phosphorylation.
|
30145544 |
2018 |
|
Thrombocytopenia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.
|
30104364 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, we conducted a case-control study including 1064 breast cancer cases and 1073 cancer-free controls to evaluate the associations of 28 potentially functional polymorphisms in 12 core ARSs genes (AARS, CARS, EPRS, HARS, KARS, LARS, MARS, QARS, RARS, VARS, WARS, and YARS) with breast cancer risk.
|
24510587 |
2015 |
|
T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, in this study we applied RNA sequencing to systematically screen for altered gene expression in human NK/T-cell lymphoma cell lines YTS and SNK-6 versus normal NK cells.
|
26499190 |
2015 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, we conducted a case-control study including 1064 breast cancer cases and 1073 cancer-free controls to evaluate the associations of 28 potentially functional polymorphisms in 12 core ARSs genes (AARS, CARS, EPRS, HARS, KARS, LARS, MARS, QARS, RARS, VARS, WARS, and YARS) with breast cancer risk.
|
24510587 |
2015 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This process, applied to NPC research, determined the single RG (YARS or HPRT1) and the set of RGs (HPRT1, YARS, and EIF3S7) that are the most suitable internal controls.
|
21052085 |
2010 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
YARS localizes to axonal termini in differentiating primary motor neuron and neuroblastoma cultures.
|
16429158 |
2006 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
YARS localizes to axonal termini in differentiating primary motor neuron and neuroblastoma cultures.
|
16429158 |
2006 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
YARS localizes to axonal termini in differentiating primary motor neuron and neuroblastoma cultures.
|
16429158 |
2006 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Malignant neoplasm of testis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Carcinoma of bladder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Malignant Testicular Germ Cell Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined RT-PCR on 12 urogenital cell lines, including three prostate cancer (LNCaP, PC3, DU145), five human renal cell carcinoma (SMKT-R3, TOS-1, TOS-2, R4, ACHN), two urinary bladder cancer (YTS-1, KK-47) and two testicular cancer (NEC8, NEC14) cell lines.
|
10533904 |
1999 |
|
Peripheral Neuropathy
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Related adults heterozygous for YARS p.Pro167Thr showed no evidence of peripheral neuropathy on electromyography, in contrast to previous reports for other YARS variants.
|
30304524 |
2019 |
|
Peripheral Nervous System Diseases
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Related adults heterozygous for YARS p.Pro167Thr showed no evidence of peripheral neuropathy on electromyography, in contrast to previous reports for other YARS variants.
|
30304524 |
2019 |
|
Peripheral Neuropathy
|
0.030 |
Biomarker
|
group |
BEFREE |
Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.
|
27633801 |
2017 |
|
Neuropathy
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the mitochondria.
|
28469666 |
2017 |
|
Peripheral Nervous System Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.
|
27633801 |
2017 |
|
Neuropathy
|
0.030 |
Biomarker
|
group |
BEFREE |
Their features recapitulated several hallmarks of CMT pathophysiology and were similar to the phenotypes identified in our previously described Drosophila model of YARS-associated neuropathy.
|
24807208 |
2014 |