|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found new characteristic of thyroid tumours: methylation of TP73, WIF1 and PDLIM4 TSGs, which can contribute to thyroid neoplasia.
|
31006665 |
2019 |
|
Osteoporotic Fractures
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Similarly, individuals carrying the C-allele at PDLIM4 rs3900945 were predisposed to osteoporotic fracture (adjusted OR = 1.45; 95% CI: 1.05-1.25; <i>P</i><0.001).
|
30578378 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of PDLIM4 is correlated with advanced tumor stage and lymph node metastasis.
|
31376371 |
2019 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer.
|
31376371 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer.
|
31376371 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer.
|
31376371 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The current study aimed at producing recombinant IL-23 decoy receptor (RIL-23R) using hAD-MSCs as a good candidate for <i>ex vivo</i> cell-based gene therapy purposes to reduce inflammation in autoimmune diseases. hAD-MSCs was isolated from lipoaspirate and then characterized by differentiation.
|
30307322 |
2018 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cervical cancer remain largely unknown.
|
29126926 |
2018 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cervical cancer remain largely unknown.
|
29126926 |
2018 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Though LIM-domain protein AJUBA was identified as a putative oncogene, the function and underlying mechanisms of AJUBA in cervical cancer remain largely unknown.
|
29126926 |
2018 |
|
Postoperative cognitive dysfunction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The levels of HOMA2-IR in patients with POCD were significantly higher than those of patients without POCD at 6h and 7days after operation (P<0.05).The levels of serum IL-6 and TNF- α were positively correlated with HOMA2-IR value at 6h after operation (RIL-6=0.426, P<0.01; RTNF-a=0.381, P<0.01).
|
28048971 |
2017 |
|
Malignant mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.
|
24336325 |
2015 |
|
Breast adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition (EMT) of a breast adenocarcinoma cell line.
|
24657059 |
2014 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the genes suggested to play an important role in the pathophysiology of bipolar disorder (BPD) is PDLIM5, which encodes LIM domain protein.
|
23031404 |
2012 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
|
22695491 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
|
22154084 |
2012 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
|
22695491 |
2012 |
|
Early-Stage Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumors from 193 patients with early stage breast cancer who received no adjuvant systemic therapy were used to analyze methylation levels of RIL, HIN-1, RASSF1A and CDH13 genes for associations with known predictive and prognostic factors and for impact on time to first recurrence and overall survival.
|
22695491 |
2012 |
|
Myeloid Leukemia, Chronic
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, DNA methylation of PDLIM4 may help identify a subset of CML patients that would benefit from treatment with Src/Abl inhibitors.
|
21760961 |
2011 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we have shown that the LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in vitro and in human hepatoma and colon carcinoma cell lines and mouse embryonic fibroblasts.
|
21060154 |
2010 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we have shown that the LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in vitro and in human hepatoma and colon carcinoma cell lines and mouse embryonic fibroblasts.
|
21060154 |
2010 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Restoring RIL expression in colon cancer cells by stable transfection resulted in reduced cell growth and clonogenicity and an approximately 2.0-fold increase in apoptosis following UV exposure.
|
17332327 |
2007 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In a variety of primary tumors, we found RIL methylation in 55 of 92 (60%) cases, with highest methylation in AML and colon cancer, and in 30 of 83 (36%) MDS samples, whereas normal tissues showed either absence or substantially lower levels of methylation, which correlates with age.
|
17332327 |
2007 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
In a variety of primary tumors, we found RIL methylation in 55 of 92 (60%) cases, with highest methylation in AML and colon cancer, and in 30 of 83 (36%) MDS samples, whereas normal tissues showed either absence or substantially lower levels of methylation, which correlates with age.
|
17332327 |
2007 |
|
Triple Negative Breast Neoplasms
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The subset of triple-negative breast cancers (in other words, those with negative ER, PR, and HER-2/neu status) was positively associated with the methylation of the RIL/CDH13 panel and negatively associated with the HIN-1/RASSF1A panel.
|
17764565 |
2007 |