|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case report.
|
28693140 |
2017 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.
|
26546613 |
2016 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The results show that genes involved in functional gene modules, such as CD160 (rs744877) and RUNX1 (rs2051179), are especially relevant to RA, which is supported by previous reports.
|
22449398 |
2012 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
We conducted population-based association tests for the four selected SNPs (rs2240340/padi4_94, rs7528684/fcrl3_3, rs3792876/slc2F2 and rs2268277/runx1) previously reported to be associated with rheumatoid arthritis (RA).
|
18087673 |
2008 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Data of the current study do not confirm the universal and population independent susceptibility role of the SLC22A4 C6607T and RUNX1 G24658C variants for rheumatoid arthritis; furthermore, the data presented here show, that there are no significant carnitine-metabolism associated functional consequences of the different genotypes evidenced by the lack of detectable differences in the carnitine ester profiles.
|
18328148 |
2008 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.
|
18087673 |
2008 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
No influence of SLC22A4 C6607T and RUNX1 G24658C genotypic variants on the circulating carnitine ester profile in patients with rheumatoid arthritis.
|
18328148 |
2008 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The SLC22A4 and RUNX1 polymorphisms described as etiological in the Japanese study did not show a significant role in RA susceptibility in our population.
|
16652416 |
2006 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to RA in the Spanish population.
|
16821265 |
2006 |
|
Rheumatoid Arthritis
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
Moreover, it has been shown that multiple genetic variants in one pathway (both in a transcription factor, RUNX-1, as in the transcription factor binding site of RUNX1 in the SLC22A4 gene) can each confer very small risks but by gene-gene interactions can confer a ninefold risk for rheumatoid arthritis.
|
15838240 |
2005 |
|
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
SLC22A4 and RUNX1: identification of RA susceptible genes.
|
15184985 |
2004 |
|
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.
|
15184985 |
2004 |
|
Rheumatoid Arthritis
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder.
|
14608356 |
2003 |