Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Of the pure GGOs, 9 (25%) nodules were classified as AIS, 10 (27.8%) nodules were classified as MIA and 22 (57.9%) of the mGGOs were lung cancer.
|
31426812 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.
|
31009812 |
2019 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
TTF-1 and napsin A for lung adenocarcinoma, p40 for squamous lung cancer, GATA3 and mammaglobin for breast cancer, or synaptophysin and chromogranin A for neuroendocrine tumors).
|
30354850 |
2019 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among them, TP63 (3q28), RP11-650L12.2 (15q25.1) and CHRNA5 (15q25.1) were located in known lung cancer susceptibility loci.
|
29193083 |
2018 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Kaplan-Meier analysis showed that only tumor invasion status (IAD vs AIS/MIA, p = 0.003) could predict 5-year lung cancer-specific overall survival (LCS-OS), and IAD had a worse LCS-OS than AIS and MIA.
|
30096292 |
2018 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that TP63 rs7631358 G > A and CSF1R rs10079250 A > G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.
|
28449811 |
2017 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs), rs6790167 (g243059A>G) in intron 9 of TP63 and rs1535045 (g6194C>T) in intron 1 of CD40 respectively, may affect the susceptibility of lung cancer.
|
27063419 |
2016 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
There were 8 cases of MEC-like pulmonary carcinoma aged 36-78 years: 2 cases were located in the bronchus, and 6 cases were located in the lung. p63 and TTF-1 were positive in all cases (8/8), p40 was positive in 5 cases (5/8), and ALK was positive in 5 cases (5/8).
|
26575266 |
2015 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
To improve segregation between ADC and SqCC in small samples, the classification of lung cancer was updated in 2011, adding immunohistochemistry (IHC) for p63 and TTF-1 to the diagnostic algorithm.
|
25982011 |
2015 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our observations provide evidence that genetic variation in HLA Class II and TP63 may modify the association between HAP and lung cancer risk.
|
25566987 |
2015 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] rs13009079T>C) were found to be significantly associated with lung cancer in the same direction as the discovery set.
|
25144241 |
2014 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Quantitative assessment of the influence of TP63 gene polymorphisms and lung cancer risk: evidence based on 93,751 subjects.
|
24466311 |
2014 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results, combined with those from previous studies, suggest that genetic variation in TP63 may influence lung cancer susceptibility in the Han population.
|
24092572 |
2014 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore.
|
22367405 |
2012 |
Carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Although p63 and its isoforms are overexpressed in a wide variety of human malignancies such as cervical, head and neck, and lung cancer, their role in endometrial carcinoma has not been investigated.
|
22441934 |
2012 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
|
23143601 |
2012 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
This minimalist IHC-based model of p40 and TTF1 on biopsy/cellblock samples was effective to correctly subtype most cases of lung cancer.
|
22071786 |
2012 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
|
21725308 |
2011 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
Carcinoma of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common set of genes dysregulated in lung cancer was obtained, including BPA1, DUSP6, ASCL1, RNAS1 and S100P. p63 and CK 5/6 p63 are useful for differentiating adenocarcinoma and small cell lung cancer from squamous cell carcinoma.
|
20332665 |
2010 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we tested whether genomic gains in six specific loci, TP63 on 3q28, EGFR on 7p12, MYC on 8q24, 5p15.2, and centromeric regions for chromosomes 3 (CEP3) and 6 (CEP6), may provide further value in the prediction of lung cancer.
|
19547694 |
2009 |
Carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Transient expression of p63 transactivated the maspin promoter with remarkable fold changes in cells expressing the TAp63, suggesting that TAp63 might be a novel stimulator of the maspin promoter in lung cancer.
|
15466179 |
2004 |
Carcinoma of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
These observations suggest that p63 genomic amplification has an early role in lung tumorigenesis and deserves additional evaluation as a biomarker for lung cancer progression.
|
14612504 |
2003 |
Carcinoma of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Thus, p51 expression is low or absent in a subset of lung cancer.
|
10935472 |
1999 |