AOC3, amine oxidase copper containing 3, 8639

N. diseases: 106; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE Here, we examined if plasma VAP-1/SSAO is a biomarker for CAD diagnosed by coronary angiography in humans and investigated the effect of VAP-1/SSAO inhibition by a specific inhibitor PXS-4728A on atherosclerosis in cell and animal models. 29653075 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE In conclusion, VAP-1/SSAO inhibition reduces atherosclerosis and may act through suppression of several important mechanisms for atherosclerosis. 29915377 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE Vascular adhesion protein-1 (VAP-1) is secreted by vascular smooth muscle cells, adipocytes and endothelial cells with functional monoamine oxidase activity and is elevated in atherosclerosis, diabetes mellitus and obesity. 28044236 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE Our results suggest for the first time VAP-1 as a potential imaging target for inflamed atherosclerotic plaques, and corroborate VAP-1 inhibition as a therapeutic approach in the treatment of atherosclerosis. 27731409 2016
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.050 Biomarker disease BEFREE Cytotoxic metabolites by SSAO may cause endothelial injury and subsequently induce atherosclerosis. 16487546 2006