AOC3, amine oxidase copper containing 3, 8639

N. diseases: 106; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 AlteredExpression disease BEFREE Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively. 30022055 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 Biomarker disease BEFREE VAP-1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. 29364582 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 Biomarker disease BEFREE Synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes: functional analysis by gene ontology. 18413170 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 AlteredExpression disease BEFREE It is possible that the increased SSAO activity in diabetes may be a result of up-regulation due to increase of SSAO substrates, such as methylamine or aminoacetone. 16487546 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 Biomarker disease BEFREE Plasma SSAO correlated positively with duration of diabetes, HbA(1)c and plasma renin, and negatively with plasma angiotensinogen and body mass index. 15830186 2005
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 AlteredExpression disease BEFREE The increased SSAO activity in diabetes is most likely dependent on post-transcriptional modifications or activation of existing inactive enzyme molecules. 15541390 2004
CUI: C0011847
Disease: Diabetes
Diabetes
0.070 Biomarker disease BEFREE No wild-type animals displayed this phenotype.In conclusion, we suggest that this transgenic mouse model may be of great value for increasing the knowledge about to what extent human SSAO contributes to vascular complications in diabetes, and also to which extent inhibition of SSAO can prevent the development of such complications. 12686114 2003