Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RUNX3 methylation was also detected in hepatocellular carcinomas (73%, n=48), larynx cancers (62%, n=37), lung cancers (46%, n=24), breast cancers (25%, n=25), prostate cancers (23%, n=44), endometrial cancers (12.5%, n=24), colon cancers (4.9%, n=61) and uterine cervical cancers (2.5%, n=40), showing that RUNX3 methylation is not restricted to gastric cancer.
|
14968123 |
2004 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RUNX3 is mapped to 1p36, which is frequently deleted in hepatocellular carcinomas (HCC), therefore, these tumors were investigated for expression and copy number changes of RUNX3 and other Runt-related genes, RUNX1, RUNX2, and their co-factor CBFP.
|
17094378 |
2006 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
RUNX3 protein expression was frequently inactivated in the HCC cell lines (91%) and tissues (90%).
|
21205319 |
2011 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
|
21328447 |
2011 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
RUNX3 expression is deleted or decreased in HCCs and cell lines, in association with progression and prognosis.
|
22296371 |
2011 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RUNX3 may be recommended as an effective prognostic indicator and therapeutic target for patients with HCC.
|
28977878 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An inverse correlation between RUNX3 and MRP expression was observed in the HCC tissues.
|
26985715 |
2016 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An inverse correlation was observed between RUNX3 expression and JAG1 expression in most HCC cell lines and tissues.
|
21637926 |
2011 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma.
|
14760761 |
2004 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
However, whether oxidative stress and RUNX3 hypermethylation in HCC have a cause- and-effect relationship is not known.
|
26225676 |
2015 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Methylation of tumour suppressor genes <i>RUNX3, RASSF1A</i> and <i>E-Cadherin</i> in HCV-related liver cirrhosis and hepatocellular carcinoma.
|
31790342 |
2020 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
miR-106b-5p may serve as a potent prognostic marker for tumor recurrence and survival of HCC patients. miR-106b-5p may exert an oncogenic role in HCC via regulating its target gene RUNX3.
|
31503422 |
2019 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Notably, hypermethylation of RUNX3 appeared in 70% (14/20) of human hepatocellular carcinomas.
|
28458013 |
2017 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Notably, hypermethylation of RUNX3 appeared in 70% (14/20) of human hepatocellular carcinomas.
|
28458013 |
2017 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Our findings indicate that promoter hypermethylation of RUNX3 gene may occur as an early event in the development of HCC and that methylation may be a major mechanism for inactivation of RUNX3 gene in HCC.
|
16155404 |
2005 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings indicate that promoter hypermethylation of RUNX3 gene may occur as an early event in the development of HCC and that methylation may be a major mechanism for inactivation of RUNX3 gene in HCC.
|
16155404 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study revealed the role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC.
|
30520539 |
2019 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Pooled odds ratio for RUNX3 promoter methylation status in hepatocellular carcinoma versus control liver tissue was 24.37 (95%CI: 12.14, 48.92), p < .00001, indicates a strong association between methylation of the RUNX3 promoter and hepatocellular carcinoma.
|
25664646 |
2015 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarly, mRNA expression of E-cadherin was also significantly correlated with that of RUNX3 in low-EMT HCC, while mRNA expression of JAG1 was negatively correlated with that of RUNX3.
|
22488108 |
2012 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings indicate that RUNX3 suppresses Notch signaling in HCC SMMC7721 cells by its interaction with ICN1 and thus recruitment to the RBP-J recognition motif of downstream genes of Notch signaling.
|
19800882 |
2010 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data provide a new mechanism of miR-20a regulating RUNX3 in HCC.
|
27748919 |
2016 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The methylation levels of six genes (APC, CDKN2A, GSTP1, RASSF1A, SFRP1 and RUNX3) were significantly higher in HCCs than in adjacent NTs (P<0.05).
|
21600201 |
2011 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ORs of RUNX3 methylation were 16.6 (95%CI = 6.5-42.4) for tumor tissues relative to tumor-adjacent tissues in patients with HCC, 67.3 (95%CI = 13.0-348.5) for tumor tissues from patients with HCC relative to liver tissues from patients with non-neoplastic liver diseases, and 3.26 (95%CI = 1.54-6.90) for tissues from patients with hepatitis C virus (HCV)- related HCC relative to liver tissues from patients with HCC unrelated to HCV.
|
25061743 |
2014 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Therefore, we examined genetic and epigenetic alterations of RUNX3 in human HCC.
|
15780064 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This in turn indicated that RUNX3 could be an early diagnostic marker distinguishing benign from malignant hepatocellular carcinoma.
|
27420934 |
2016 |