Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
RUNX3 aberrant methylation might play an important role in colorectal cancers, especially in poorly-differentiated colorectal cancers.
|
16080503 |
2005 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RUNX3 copy number predicts the development of UC-associated colorectal cancer.
|
21109941 |
2011 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RUNX3 mRNA and protein expressions were down-regulated in response to hydrogen peroxide (H(2)O(2)) in the human colorectal cancer cell line SNU-407.
|
22274925 |
2012 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer.
|
30692634 |
2019 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All in all, our findings may provide insight into the development of RUNX3 for CRC metastasis diagnostics and therapeutics.
|
27633042 |
2016 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apart from SEPT9, other methylated biomarkers including tachykinin-1 (TAC1), somatostatin (SST), and runt-related transcription factor 3 (RUNX3) have been shown to effectively detect CRC in a multitude of sample types.
|
30944663 |
2019 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CIMP status was also determined by methylation-specific quantitative PCR method (MethyLight) using eight CIMP markers (MLH1, NEUROG1, CRABP1, CACNA1G, CDKN2A (p16), IGF2, SOCS1, and RUNX3) in 216 MSI-H CRCs.
|
25973084 |
2015 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Despite higher levels of EZH2 and lower levels of RUNX3 in CRC specimens in general, no inverse correlation between EZH2 and RUNX3 in paired samples was found arguing against a major role for histone methylation in silencing RUNX3 in CRC.
|
20631058 |
2010 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of the differential expression between carcinoma and normal mucosa showed that SMAD3 rs12708491 and rs2414937, NFκB1 rs230510 and rs3821958, and RUNX3 rs6672420 were associated with several miRNAs for colorectal carcinoma.
|
28061442 |
2017 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpression of DLC-1 and RUNX3 revealed antitumor effects in CRC cell lines with the inhibition of cell proliferation, migration and invasion, and the induction of cell apoptosis.
|
30362160 |
2019 |
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
However, no study to date has examined interrelationship between TGFBR2 mutation, RUNX3 methylation, and CIMP in colorectal cancer.
|
17270239 |
2007 |
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, hypermethylation of RUNX3 was detected in 70 out of 105 colorectal carcinomas (66.7%).
|
24403453 |
2014 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, the combined methylation status of p16, p14, HLTF, CDH13 and RUNX3 was examined in 59 resected primary colorectal cancers using methylation-specific PCR and the methylation status was correlated with the clinicopathological features of the affected patients.
|
16475679 |
2006 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.
|
30763934 |
2020 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lower positive expression rate of RUNX3 and higher positive expression rate of Notch1 and Jagged 1 were observed in CRC tissues than those in normal adjacent tissues with a negative correlation, and the expression levels were associated with the differentiation degree, TNM staging, lymph node metastasis and tumor invasion depth (all P<0.05).
|
28498402 |
2017 |
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, we investigated the relationship between RUNX3 promoter methylation and MSI in colorectal cancer.
|
20682997 |
2010 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the 62 CRC tissue samples, 20 (32.3%) presented hypermethylated RUNX3 promoters.
|
29333422 |
2018 |
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our data suggest that RUNX3 inactivation due to promoter hypermethylation in colorectal polyps represents an early event in colorectal cancer (CRC) progression.
|
19174785 |
2009 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous study showed that RUNX3 inhibits invasiveness by preventing vascular endothelial growth factor secretion and suppressed endothelial cell growth and tube formation in colorectal cancer (CRC).
|
31278361 |
2020 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results verified the reliability of using serum RUNX3 and SFRP1 methylation status as a noninvasive biomarker for diagnosis of CRC and that combined detection of RUNX3/SFRP1/CEA panel might be a promising strategy for early detection of CRC.
|
31524773 |
2019 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer.
|
20442291 |
2010 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The RUNX3 rs2236852 AA genotype and A allele showed association with CRC (OR = 0.39, 95%CI = 0.21-0.73, P < 0.01; OR = 0.65, 95%CI = 0.49-0.87, P < 0.01, respectively), while the rs6672420, rs11249206, and rs760805 polymorphisms did not show significant association with CRC.
|
26634516 |
2015 |
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The aim of the present study was to examine the presence of DNA sequences of five human DNA viruses (assessed by PCR): JC polyoma virus (JCV), human adenovirus (AdV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) and human papillomavirus (HPV) in a cohort of 186 sporadic colorectal cancers (CRCs) and related these data with the methylation status of six CpG island methylator phenotype (CIMP)-specific genes (MLH1, CACNA1G, NEUROG1, IGF2, SOCS1, RUNX3) and seven cancer-related genes markers (p16, MINT1, MINT2, MINT31, EN1, SCTR and INHBB) assessed by methylation-specific PCR in 186 and 134 CRC cases, respectively.
|
21625944 |
2011 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of several tumor suppressor gene proteins, runt-related transcription factor 3 (1p36), annexin A10 (4q33), SMAD family member 4 (18q21.1), and deleted in colorectal carcinoma (18q21.3), was evaluated immunohistochemically.
|
22901464 |
2012 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of RUNX3 mRNA and protein were downregulated in response to treatment of the human colorectal cancer cell line SNU-407 with H2O2.
|
24042352 |
2013 |