Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.
|
21567391 |
2012 |
Stomach Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The transcription factor RUNX3 is a gastric tumor suppressor.
|
19706291 |
2010 |
Stomach Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our results demonstrate a loss or substantial decrease of Runx3 expression in 70 cases of gastric tumors as compared with that in normal gastric mucosa (0.5749 +/- 0.3580 vs 1.7252 +/- 0.4085, P < 0.05).
|
20492341 |
2010 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we show that H. pylori infection inactivates the gastric tumor suppressor RUNX3 in a CagA-dependent manner.
|
20676134 |
2010 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We previously identified RUNX3 as a major gastric tumor suppressor by establishing a causal relationship between loss of function and gastric carcinogenesis.
|
19682550 |
2009 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we found that RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity.
|
18772112 |
2008 |
Stomach Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.
|
18430739 |
2008 |
Stomach Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer.
|
18097595 |
2008 |
Stomach Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.
|
17591800 |
2007 |
Stomach Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Spreading of methylation within RUNX3 CpG island in gastric cancer.
|
16367921 |
2006 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions.
|
16627973 |
2006 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Genes involved in the transforming growth factor beta (TGF-beta) signaling pathway are frequently altered in several types of cancers, and a gastric tumor suppressor RUNX3 appears to be an integral component of this pathway.
|
16738314 |
2006 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
Stomach Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.
|
15386419 |
2005 |
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.
|
16140942 |
2005 |
Stomach Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia.
|
12824905 |
2003 |