SOCS1, suppressor of cytokine signaling 1, 8651

N. diseases: 315; N. variants: 7
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE BACKGROUND Recently, it was demonstrated that sup-pressor of cytokine signaling-1 (SOCS-1) was frequently silenced by methylation of its CpG island inhuman hepatocellular carcinoma (HCC). 15074307 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE Inactivation of the SOCS-1 gene by methylation has been previously described in hepatocellular carcinomas and multiple myeloma. 15121754 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE SOCS1 has been shown to have tumor-suppressor activity, and methylation of this gene, resulting in transcriptional silencing, has been found in 65% of hepatocellular carcinoma and has been suggested to play an important role in the development of the cancer. 12759928 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 AlteredExpression disease LHGDN SOCS1 has been shown to have tumor-suppressor activity, and methylation of this gene, resulting in transcriptional silencing, has been found in 65% of hepatocellular carcinoma and has been suggested to play an important role in the development of the cancer. 12759928 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 AlteredExpression disease BEFREE We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway. 12601549 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE The most frequently methylated TSGs in HCC were: SOCS-1 (65%), GSTP (54%), APC (53%), E-cadherin (49%), and p15 (49%). 12937151 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE The suppressor of cytokine signalling-1 (SOCS-1) gene is frequently silenced in human hepatocellular carcinoma by aberrant methylation. 12865927 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease LHGDN Aberrant methylation of the SOCS-1 gene was detected in 30 of 50 (60%) HCC specimens. 14614012 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE Because of the previously observed hypermethylation-associated inactivation of SOCS-1 in hepatocellular carcinoma and the critical role of interleukin-6 (IL-6) as a survival factor in multiple myeloma (MM), we examined CpG island methylation of the SOCS-1 gene in MM cell lines and primary MM samples. 12456503 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 PosttranslationalModification disease BEFREE Aberrant methylation of the SOCS-1 gene was detected in 30 of 50 (60%) HCC specimens. 14614012 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE These results indicate that the SSI-1 gene is silenced in a substantial portion of HCC though the combined mechanisms of methylation of either 5' or exon CpG rich regions and by a chromosomal loss of the remaining allele. 12183076 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE Our results also indicate therapeutic strategies for the treatment of HCC including use of SOCS-1 in gene therapy and inhibition of JAK2 by small molecules, such as AG490. 11326271 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE Expression of the SSI-1 gene was markedly reduced in half of eight HCCs analyzed. 11322203 2001