|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The insulin-signaling pathway requires insulin receptor substrate 1 (IRS1) and IRS2, which are found to be dysregulated in diabetes and obesity.
|
30770439 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Unsuppressed hepatic glucose production (HGP) contributes substantially to glucose intolerance and diabetes, which can be modeled by the genetic inactivation of hepatic insulin receptor substrate 1 (Irs1) and Irs2 (LDKO mice).
|
29867232 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in β-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling.
|
30367392 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The best evidence of this is that systemic elimination of the Irs2 in mice (Irs2(-/-)) recapitulates the pathogenesis of type 2 diabetes (T2D), in that diabetes arises as a consequence of combined insulin resistance and beta-cell failure.
|
24977713 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.
|
24289561 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide such a demonstration here by showing that the hippocampal formation (HF) and, to a lesser degree, the cerebellar cortex in AD cases without diabetes exhibit markedly reduced responses to insulin signaling in the IR→IRS-1→PI3K signaling pathway with greatly reduced responses to IGF-1 in the IGF-1R→IRS-2→PI3K signaling pathway.
|
22476197 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, we reported that TFE3 activates hepatic IRS-2 and hexokinase, participates in insulin signaling, and ameliorates diabetes.
|
22297304 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, reducing Irs2 levels throughout the body (except in β cells, where Irs2 expression is needed to prevent diabetes onset; R6/2•Irs2+/-•Irs2βtg mice) improved motor performance and extended life span.
|
21926467 |
2011 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children.
|
21771880 |
2011 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, associations identified in the GoKinD collections on chromosomes 11p15.4 (near the CARS gene) and 13q33.3 (within an intergenic region between MYO16 and IRS2) are susceptibility loci of kidney disease common to both type 1 and 2 diabetes.
|
21412220 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, lack of Igf1r function in β cells aggravates the consequences of Irs2 ablation in double mutants and results in lethal diabetes by 6 weeks of age.
|
20947509 |
2010 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While reduced IRS-2 expression is tightly associated with diabetes and insulin resistance in various rodent diabetic models, this gene is also suggested to play a critical role in reproductive system and pancreas development.
|
19251045 |
2009 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HF diet-fed Irs2(+/-) mice failed to show a sufficient increase in beta cell mass, and overexpression of Irs2 in beta cells of HF diet-fed Gck(+/-) mice partially prevented diabetes by increasing beta cell mass.
|
17200721 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
|
16327801 |
2006 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diabetes resolved when the mice were between 6 and 10 months of age: functional beta cells expressing Irs2 repopulated the pancreas, restoring sufficient beta cell function to compensate for insulin resistance in the obese mice.
|
15467829 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin receptor substrate-1 and -2 (IRS-1 and IRS-2), two major downstream molecules of IGF-1R, are known to be important in the genesis of diabetes.
|
14604996 |
2004 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, pharmacological approaches that promote Irs2 expression in beta cells, especially specific cAMP agonists, could be rational treatments for beta cell failure and diabetes.
|
14617753 |
2003 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings suggest that the association of homozygosity for the Asp1057 allele in IRS-2 with type 2 diabetes in Pima Indians may be mediated by interaction of the polymorphism with obesity on several diabetes-related traits.
|
12765968 |
2003 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IRS-2 inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance and reduced beta cell mass.
|
11030756 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
IRS-1-deficient mice are growth retarded, while IRS-2-deficient mice develop diabetes, indicating that the two molecules play a more specific role than previously recognized in IGF-IR and IR signaling.
|
10417963 |
1999 |