Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.010 Biomarker disease BEFREE Here, we report that the eukaryotic translation initiation factor 3i (eIF3i) is required for VEGFA protein expression in both normal embryonic and tumorigenic angiogenesis. eIF3i is dynamically expressed in the early stages of zebrafish embryogenesis and in human hepatocellular carcinoma tissues. eIF3i homozygous mutant zebrafish embryos show severe angiogenesis defects and human hepatocellular cancer cells with depletion of eIF3i to induce less angiogenesis in tumor models. 25147179 2014