B3GALT4, beta-1,3-galactosyltransferase 4, 8705

N. diseases: 9; N. variants: 0
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.020 AlteredExpression disease BEFREE These data suggest that decreased B3GALT4 and GM1 expression can increase cell vulnerability to potentially toxic stressors and that such mechanisms may contribute to dopaminergic neurodegeneration in PD. 30611881 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.020 AlteredExpression disease BEFREE These data show that residual neuromelanin-containing neurons in the PD SN have decreased expression of the ganglioside biosynthetic genes B3GALT4 and ST3GAL2, consistent with previous reports of decreased levels of gangliosides GM1, GD1a, GD1b and GT1b in the PD SN. 29902255 2018