TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group BEFREE Three human prostate tumor cell lines (PC3, DU145 and LNCaP) and their bcl-2-expressing counterparts were tested for their susceptibility to TRAIL. 11439339 2001
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group BEFREE More surprisingly, depsipeptide also increased prostate tumor cell sensitivity to TRAIL-induced apoptosis. 15771957 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Therapeutic group CTD_human Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. 21209944 2010
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 AlteredExpression group LHGDN Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor. 16215673 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Therapeutic group CTD_human Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential. 17718901 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Therapeutic group CTD_human APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy. 16368536 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 AlteredExpression group LHGDN Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosis. 18726983 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group LHGDN S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. 17431115 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group BEFREE The expression of one of these FOXO-regulated genes, TRAIL, a pro-apoptotic member of the tumor necrosis factor family, was decreased in human metastatic prostate tumors. 12351634 2002
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group BEFREE These results further define Ad5-TRAIL as a novel anti-tumor therapeutic and demonstrate its potential use as a means for treating prostate tumors, as well as other solid tumors, in vivo. 11545617 2001
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Therapeutic group CTD_human Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. 17636462 2007