|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Acquired Immunodeficiency Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings suggest the possible involvement of Bcl-xL in Act D-induced sensitization of AIDS-KS cells to Apo-2L-mediated apoptosis.
|
10228045 |
1999 |
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation.
|
11442750 |
2001 |
|
Acute HIV infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because the TRAIL pathway has been implicated in CD4 T cell death occurring during HIV-1 infection, we used short hairpin RNA knockdown, CRISPR deletion, or Abs specific for TRAILshort to determine the effect of inhibiting TRAILshort on the outcome of experimental acute HIV infection in vitro.
|
31189571 |
2019 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore examined 129 cell samples from patients with de novo acute leukemia as to their constitutive susceptibility to TRAIL-induced apoptosis In vitro.
|
11417478 |
2001 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa.
|
23828551 |
2013 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.
|
22408264 |
2012 |
|
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Cytotoxic drugs enhance the ex vivo sensitivity of malignant cells from a subset of acute myeloid leukaemia patients to apoptosis induction by tumour necrosis factor receptor-related apoptosis-inducing ligand.
|
12780785 |
2003 |
|
Acute Myeloid Leukemia, M1
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Cytotoxic drugs enhance the ex vivo sensitivity of malignant cells from a subset of acute myeloid leukaemia patients to apoptosis induction by tumour necrosis factor receptor-related apoptosis-inducing ligand.
|
12780785 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that in both acute promyelocytic leukemia and breast cancer cells the retinoic acid (RA) and interferon signaling pathways converge on the promoter of the tumoricidal death ligand TRAIL.
|
15241475 |
2004 |
|
Acute Undifferentiated Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors.
|
22406996 |
2012 |
|
Acute Undifferentiated Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We recently showed that TRAIL is able to target leukemia stem cell surrogates.
|
23744361 |
2013 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, using the first described C57BL/6 (B6) TRAIL-sensitive experimental tumor models, we have characterized the innate and adaptive immune components involved in the primary rejection phase of an anti-mouse DR5 (mDR5) mAb, MD5-1 in established MC38 colon adenocarcinomas.
|
20505139 |
2010 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
BEFREE |
These results suggest that Adv-caspase-8 may be a good combination partner of TRAIL and enables TRAIL to be a more potent anticancer agent in a wide range of adenocarcinoma cells which demonstrate low expression of caspase-8.
|
15645141 |
2005 |
|
Adenocarcinoma
|
0.070 |
GeneticVariation
|
group |
BEFREE |
In this study, three different lung cancer cell lines and three different primary cell cultures established from patients with lung cancer (two patients with squamous cell lung carcinoma and one with adenocarcinoma) were screened for sensitivity to adenoviral delivery of TRAIL.
|
17187448 |
2007 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
LHGDN |
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.
|
16751802 |
2006 |
|
Adenocarcinoma
|
0.070 |
GeneticVariation
|
group |
LHGDN |
Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
|
15041704 |
2004 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
LHGDN |
HDAI may be useful as an adjuvant agent for TRAIL in the treatment of human colonic adenocarcinomas that are resistant to TRAIL.
|
11956660 |
2002 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/Apo2L has been recently identified as important in promoting programmed cell death in breast and colon adenocarcinomas.
|
10960444 |
2000 |
|
Adenocarcinoma of colon
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Additionally, mRNA levels of fucosyltransferase 3 (FUT3) and 6 (FUT6) were found to be high in the TRAIL-sensitive colon adenocarcinoma cell line COLO 205.
|
30589515 |
2019 |
|
Adenocarcinoma of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
|
22555452 |
2012 |
|
Adenocarcinoma of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
We demonstrated an immediate impact of Mcl-1 protein level manipulations on the course of early acute apoptotic response of colon adenocarcinoma cells to TRAIL.
|
19782681 |
2009 |
|
Adenocarcinoma of colon
|
0.040 |
Biomarker
|
disease |
BEFREE |
Modified PAMAM vehicles for effective TRAIL gene delivery to colon adenocarcinoma: in vitro and in vivo evaluation.
|
30095012 |
2018 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenoviral vector Ad/TRAIL-F/RGD with a tumor-specific human telomerase reverse transcription promoter was used to transfer TRAIL gene to human esophageal adenocarcinoma and normal human lung fibroblastic cells (NHLF).
|
16580499 |
2006 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Therapeutic
|
disease |
CTD_human |
Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
|
24345465 |
2014 |