|
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Starting from the BXPC3 cell line, we generated and profiled a TRAIL-resistant model of pancreatic cancer, testing the impact of the combined treatment <i>in vitro</i> with specific cytotoxicity and metabolic assays.
|
30809285 |
2019 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Starting from the BXPC3 cell line, we generated and profiled a TRAIL-resistant model of pancreatic cancer, testing the impact of the combined treatment <i>in vitro</i> with specific cytotoxicity and metabolic assays.
|
30809285 |
2019 |
|
Laryngeal Squamous Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> The effect of ZD55-TRAIL combined with DOX on cell growth was assessed in LSCC Hep2 cells and normal cells by MTT assay.
|
31114365 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Results:</b> The model predicts apoptosis of CTCs within 2 h when treated with membrane bound TRAIL, while apoptosis in CTCs treated with soluble TRAIL proceeds much more slowly over the course of 10 h, consistent with previous experiments.
|
30460191 |
2018 |
|
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> treatment of nude mice bearing human TRAIL-resistant liver cancer xenografts with AAV-TRAIL-miR-221-Zip also led to growth inhibition.
|
28900506 |
2017 |
|
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> treatment of nude mice bearing human TRAIL-resistant liver cancer xenografts with AAV-TRAIL-miR-221-Zip also led to growth inhibition.
|
28900506 |
2017 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> treatment of nude mice bearing human TRAIL-resistant liver cancer xenografts with AAV-TRAIL-miR-221-Zip also led to growth inhibition.
|
28900506 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<i>In vivo</i>, therapeutic activity of MSC.TRAIL was shown upon peritumoral injection in a Colo205 xenograft tumor model.
|
28553285 |
2017 |
|
Neoplasm Metastasis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
<i>XB130</i> Knockdown Inhibits the Proliferation, Invasiveness, and Metastasis of Hepatocellular Carcinoma Cells and Sensitizes them to TRAIL-Induced Apoptosis.
|
30246718 |
2018 |
|
Thyroid Neoplasm
|
0.060 |
Biomarker
|
disease |
BEFREE |
(1) We discuss how loss of TRAIL mediated apoptosis occurred in thyroid cancer cells and how different strategies can be used to restore apoptosis in resistant cancer cells; (2) We provide detailed account of seemingly opposite roles of NOTCH signaling in thyroid cancers; (3) TGF/SMAD mediated signaling also needs detailed research because of context dependent role in thyroid cancer.
|
29243843 |
2018 |
|
Malignant neoplasm of thyroid
|
0.050 |
Biomarker
|
disease |
BEFREE |
(1) We discuss how loss of TRAIL mediated apoptosis occurred in thyroid cancer cells and how different strategies can be used to restore apoptosis in resistant cancer cells; (2) We provide detailed account of seemingly opposite roles of NOTCH signaling in thyroid cancers; (3) TGF/SMAD mediated signaling also needs detailed research because of context dependent role in thyroid cancer.
|
29243843 |
2018 |
|
Thyroid carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
(1) We discuss how loss of TRAIL mediated apoptosis occurred in thyroid cancer cells and how different strategies can be used to restore apoptosis in resistant cancer cells; (2) We provide detailed account of seemingly opposite roles of NOTCH signaling in thyroid cancers; (3) TGF/SMAD mediated signaling also needs detailed research because of context dependent role in thyroid cancer.
|
29243843 |
2018 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
(3) In mixed subcutaneous (s.c.) xenografts TRAIL-MSC inhibited CRC-tumour growth presumably by apoptosis induction but a substantial proportion of TRAIL-MSC within the total tumour cell number was needed to yield such anti-tumour effect.
|
19508388 |
2010 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
(3) Trans well invasion assay was used to examine the effects of CXCR7 silencing and/or TRAIL on MCF-7 cell invasive migration.
|
25894375 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
(4) Systemic application of TRAIL-MSC had no effect on the growth of s.c. DLD-1 xenografts which appeared to be due to a pulmonary entrapment and low rate of tumour integration of TRAIL-MSC.
|
19508388 |
2010 |
|
Malignant tumor of colon
|
0.400 |
Therapeutic
|
disease |
CTD_human |
17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines.
|
15993848 |
2005 |
|
Colonic Neoplasms
|
0.350 |
Therapeutic
|
group |
CTD_human |
17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines.
|
15993848 |
2005 |
|
Colonic Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
|
17513605 |
2007 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-FU pretreatment downregulated cellular FLICE-inhibitory protein (cFLIP) and specific cFLIP downregulation by small interfering RNA was sufficient to sensitise TRAIL-resistant HCC cell lines for TRAIL-induced apoptosis.
|
15105837 |
2004 |
|
Tumor necrosis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines that promotes apoptosis.
|
11360196 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Melanoma cell lines were treated with IFN-beta for 16-24 h before treatment with TRAIL/Apo2L.
|
12097388 |
2002 |
|
Chronic Lymphocytic Leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
B chronic lymphocytic leukemia (B-CLL) cells express several members of the tumor necrosis factor (TNF) family, such as CD40L, CD30L, and TRAIL.
|
16270354 |
2006 |
|
Mesothelioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Mesothelioma cells within the tumor spheroids exhibited striking resistance to apoptotic agents such as TRAIL plus gemcitabine that were highly effective against monolayers.
|
18511708 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
|
20661477 |
2010 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV infection induced apoptosis of primary human hepatocytes through the TRAIL-mediated pathway.
|
22087337 |
2011 |