Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE We demonstrated that our oncolytic vector (Ad5/35.IR-E1A/TRAIL) induced apoptosis in human tumor cell lines derived from colorectal, lung, prostate, and liver cancer. 15093180 2004
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 AlteredExpression disease BEFREE Our results reveal a new AP-1 site within the TRAIL promoter functionally involved in TGF-beta-induced TRAIL expression and apoptosis in hepatomas and thus provide evidence for the underlying mechanism by which TGF-beta might regulate cell death in liver cancer. 18644981 2008
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Therapeutic disease CTD_human Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. 18980244 2008
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE To establish the combined anti-tumor therapeutic effect of endostatin and soluble TRAIL (sTRAIL), we performed intra-tumoral human endostatin and sTRAIL gene transfer using plasmid pVAX1 as a vector in a nude mouse model of human liver cancer. 19223770 2009
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE TRAIL-secreting mesenchymal stem cells promote apoptosis in heat-shock-treated liver cancer cells and inhibit tumor growth in nude mice. 24451114 2014
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE The study aimed to explore the role of RIP and c-FLIP genes in TRAIL induced liver cancer cell HepG2 and Hep3B apoptosis and related mechanism. 26261530 2015
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE Since the cancer stem cells (CSCs) are believed to be responsible for the treatment failure in multiple cancers including hepatocellular carcinoma (HCC), the aim of this study was to investigate the strategies to increase the sensitivity of liver cancer stem cells (LCSCs) to TRAIL. 27840896 2016
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation. 28119237 2017
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE <i>In vivo</i> treatment of nude mice bearing human TRAIL-resistant liver cancer xenografts with AAV-TRAIL-miR-221-Zip also led to growth inhibition. 28900506 2017
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE For the first time, it was shown the possibility to induce the exogenous expression of the pro-apoptotic gene TRAIL and p53 in a liver cancer HepG2 cells via a sonoporation procedure. 30181808 2018
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE The aim of this study was to look into the approaches for increasing the sensitivity of liver cancer stem cells (LCSCs) toward TRAIL. 30774424 2019
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.400 Biomarker disease BEFREE EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. 30896802 2019