Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we found that TRAIL could induce PARP-1 cleavage and apoptosis in colon cancer HCT116 cell, but HT-29 cell was not sensitive to TRAIL.
|
31558316 |
2019 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the combination of 3-BP and TRAIL can be a promising therapeutic strategy for treatment of colon cancer.
|
31491344 |
2019 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the increased BECN1 accompanied by enhanced autophagy activity is responsible for the TRAIL resistance, and a combination of TRAIL with a PIK3C3-BECN1 inhibitor is a promising therapeutic approach for the treatment of colon cancer.
|
31092562 |
2019 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study we have tested LUV-TRAIL in several human colon cancer cell lines with different sensitivity to sTRAIL.
|
27725224 |
2016 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation.
|
26517672 |
2016 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
TRAIL is pro-apoptotic on colon cancer cells, while not cytotoxic towards normal healthy cells.
|
26771233 |
2016 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we report that gefitinib and TRAIL in combination produce a potent synergistic effect on TRAIL-sensitive human colon cancer HCT116 cells and an additive effect on TRAIL-resistant HT-29 cells.
|
27629794 |
2016 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation.
|
27421828 |
2016 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the current study, we established a TRAIL-resistant human colon cancer DLD-1 cell line to clarify the mechanisms of TRAIL-resistance and developed agents to cancel its machinery.
|
26304927 |
2015 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL.
|
25672292 |
2015 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, knockdown of survivin sensitized colon cancer cells to resistant of TRAIL-induced apoptosis.
|
26063410 |
2015 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.
|
25113506 |
2014 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we attempted to develop a multimodality approach using chemotherapeutic agent mitomycin C, biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), and mild hyperthermia to treat colon cancer.
|
25156145 |
2014 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells, and tested these MSCs, termed MSC.sTRAIL, in combination with conventional chemotherapeutic drug treatment in colon cancer models.
|
23429289 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors.
|
23732517 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colon cancer (HCT116, SW480), prostate cancer (PC3, LNCaP) and leukemia (K562) cells were treated with STI571 and TRAIL.
|
22462553 |
2012 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of silibinin and TRAIL in an in vitro model of human colon cancer progression, consisting of primary colon tumor cells (SW480) and their derived TRAIL-resistant metastatic cells (SW620).
|
22555452 |
2012 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to further confirm the antitumor activity of oncolytic virus-armed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy in xenografts, which derived from the tumors of patients with colon cancer.
|
21183948 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The in vivo capability of 2-14 to sensitize colon cancer cells to TRAIL-induced apoptosis was evaluated in a syngenic colon cancer model in which CT26-derived grafts were induced in mice.
|
21817114 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde.
|
21513580 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
|
20661477 |
2010 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intracellular esterase activity, sub-G(1) cell cycle arrest, and caspase-8, -9, and -3 activity assays revealed that gossypol potentiated TRAIL-induced apoptosis in human colon cancer cells.
|
20837473 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the light of recent data concerning TRAIL receptor distribution, we contribute further by presenting DR5 as the most frequently upregulated DR in colon cancer.
|
19637313 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we constructed pcDNA3.1-Egr-1-TRAIL (pEgr.1-TRAIL) recombinant plasmid and evaluated its effect on human colon cancer cell line SW480. pEgr.1-TRAIL transfection combined with radiotherapy caused dramatically elevation of TRAIL expression both in mRNA and protein levels, much lower radiobiological parameters in clonogenic assays, accompanied by remarkably increase in apoptosis ratio.
|
19724854 |
2009 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines.
|
19352384 |
2009 |