TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. 29167318 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE We postulated that the metabolic stress induced by the diabetes drug metformin would sensitize breast cancer cells to TRAIL receptor agonists. 28324269 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE Here we review TRAIL biological actions, its effects on the immune system, and how and to what extent it has been shown to protect against diabetes. 25759846 2015
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 GeneticVariation disease BEFREE We examined the development of atherosclerosis and diabetes in Apoe (-/-), Trail (also known as Tnfsf10)( -/- ) Apoe ( -/- ) and Trail ( -/- ) mice that were fed a high-fat diet. 21965021 2011
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE It has recently been reported that tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) plays various roles in such autoimmune diseases as diabetes, multiple sclerosis (MS), and systemic lupus erythematosus (SLE). 18348311 2008
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE In addition, blocking of TRAIL function using soluble TRAIL receptors facilitates the onset of diabetes. 18247339 2008