TNFSF10, TNF superfamily member 10, 8743

N. diseases: 295; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Reactive oxygen species contribute to TRAIL receptors upregulation; the mechanism for PH II-7 augmenting TRAIL induced apoptosis in leukemia cells. 25446561 2015
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. 25293521 2015
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. 24008770 2014
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia. 22665066 2013
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Moreover, human TRAIL+ T cells mediated enhanced in vitro cytotoxicity against both human leukemia cell lines and against freshly isolated chronic lymphocytic leukemia (CLL) cells. 23676461 2013
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE In conclusion, our data suggest that TRAIL targets leukemia-initiating cells derived from pre-B ALL xenografts in vitro and in vivo, and hence constitutes an attractive candidate drug for treatment of ALL. 22408264 2012
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE It enhanced cytotoxicity in TRAIL-treated K562 leukemia cells and reduced TRAIL-induced apoptosis in HCT116 and SW480 colon cancer cells, while having no effect on PC3 and LNCaP cells. 22462553 2012
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. 19417152 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression. 21741707 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Overall, HDACi represent a promising and safe strategy in combination with TRAIL for treatment of T-cell leukaemia. 20580868 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Expression of the TRAIL receptors in blood mononuclear cells in leukemia. 18158563 2008
CUI: C0023418
Disease: leukemia
leukemia
0.400 Therapeutic disease CTD_human [Combined effect of recombinant mutant human TRAIL and daunorubicin in inducing apoptosis of leukemia cell and its mechanism]. 17204177 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL. 17579344 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease LHGDN Retinoic acid induction of the TRAIL pathway is also operative in leukemia cells 16449964 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. 16195335 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Our study demonstrates that RA induction of the TRAIL pathway is also operative in leukemia cells lacking an RARalpha oncofusion protein and identifies RAM as a novel RA-dependent modulator of myeloid differentiation and death. 16449964 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE To investigate the basis for resistance of leukemia cells to the zinc-bound form of Apo2 ligand (Apo2L)/TRAIL, which is currently being evaluated in clinical trial, we isolated several resistant HL60 clones from parental HL60 cells by selection using the recombinant Apo2L/TRAIL. 16891471 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Bcr-Abl-expressing primary or cultured leukemia cells display high levels of the antiapoptotic heat shock protein (hsp) 70 and are resistant to cytarabine (Ara-C), etoposide, or Apo-2L/TRAIL (TNF-related apoptosis-inducing ligand)-induced apoptosis. 15388581 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Together, these findings suggest that simultaneous activation of the intrinsic and extrinsic apoptotic pathways by TRAIL and FP synergistically induces apoptosis in human leukemia cells through a mechanism that involves FP-mediated XIAP downregulation. 15385934 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE With the addition of a medium from the test group, human leukemia cell line Jurkat was activated till death (83%), indicating the secretion of active TRAIL proteins from the test cells to the medium. 11819829 2002
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE In summary, constitutive TRAIL susceptibility differs between leukemia subtypes and does not correlate with mRNA expression levels of the TRAIL receptors R1-R4 as well as constitutive NF-kappa B activation status. 11417478 2001
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE These data suggest that TRAIL might participate in CD95-independent apoptosis of lymphoid cells and might be involved in deregulated apoptosis in diseases such as leukemias and HIV-1 infection. 9485194 1998