TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression group BEFREE The results of the study showed that both PTEN and TRAIL-loaded ZNPs proved anti-proliferative activity against HepG2 cell lines with IC<sub>50</sub> values of 0.09, 0.25 µg/ml, respectively. 28140697 2017
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 AlteredExpression group BEFREE Separation by cause of disease showed that HCC TRAIL mRNA expression was lower in almost all groups than in non-cancerous tissue but most significantly lower in NASH-associated liver tumors. 25123818 2015
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE The purpose of this study was to explore whether Gli2 silencing enhances efficiency of TRAIL for hepatoma in vivo. 25535898 2014
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE Here, we describe finding the best linker, that is, sequence encoding the four amino acids IETD, to join the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene and the second mitochondria-derived activator of caspase (Smac) gene to form TRAIL-IETD-Smac and inserting it into oncolytic viral vector ZD55 to construct ZD55-TRAIL-IETD-Smac, which matched ZD55-TRAIL plus ZD55-Smac in completely eliminating xenograft hepatoma. 22530834 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5. 22400995 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE We conclude that ATRA or TRAIL resistance in AFP producing hepatoma is at least, in part, attributable to the high level of the cytoplasmic AFP. 19267404 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE Overexpressing HBc significantly decreased TRAIL-induced apoptosis of human hepatoma cells, whereas knocking-down HBc expression in hepatoma cells transfected with HBV genome enhanced it. 18927587 2009
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Therapeutic group CTD_human Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. 18980244 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 GeneticVariation group BEFREE Co-administration of soluble TRAIL (sTRAIL) gene and ACD suppressed the metastatic liver tumors of CT-26, significantly inducing apoptosis in the tumors, while such effects were not demonstrated in mice that received either the sTRAIL gene or ACD alone. 16478647 2007
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE It is possible that survivin downregulation by siRNA combined with TRAIL administration may provide a new therapeutic strategy against hepatoma. 16820920 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.400 Biomarker group BEFREE In conclusion, NF-kappaB prevents TRAIL-induced apoptosis in human hepatoma through a TRAIL-activated TRAF2-NIK-IKK pathway. 12447876 2002