Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DPSC‑differentiated osteoblasts expressing high TRAIL levels were capable to affect the cell viability of the human myeloma cell line H929, thus representing an effective anticancer therapeutic method.
|
29484421 |
2018 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The experiments provide a rationale for possible future applications of IL2-αCD38-αCD38-scTRAIL for the treatment of patients with MM or other CD38-positive malignancies.
|
29982719 |
2018 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model.
|
27998762 |
2017 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytotoxic effect of pIL6-TRAIL <sup>+</sup> -GFP <sup>+</sup> -UC-MSCs on MM growth was evaluated in SCID mice by bioluminescence and ex vivo by caspase-3 activation and X-ray imaging.
|
28962646 |
2017 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma.
|
26378933 |
2015 |
Multiple Myeloma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, rhTRAIL D269H/E195R is a potential therapy for multiple myeloma due to its high effectiveness and diminished binding to OPG.
|
24280212 |
2014 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the susceptibility of MM cells to TRAIL is largely low in most of MM cells by yet largely unknown mechanisms.
|
22389670 |
2012 |
Multiple Myeloma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because p53 directly modulates expression of death receptors, we investigated here whether p53 can modulate myeloma sensitivity to TRAIL.
|
22738917 |
2012 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Different MM cell lines were assessed for their sensitivity to recombinant human (rh) TRAIL alone and in combination with the proteasome inhibitor bortezomib, which was shown to enhance the effect of rhTRAIL.
|
22420897 |
2012 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pretreatment with bortezomib effectively overcomes APO2L/TRAIL apoptosis resistance in myeloma cell lines and in CD138+ cells while directly adhered or in transwell assay.
|
19922463 |
2010 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
More importantly, these molecular changes induced by ATO-treated myeloma cells are very similar to the baseline expression pattern of hyperdiploid myeloma, which has a relative good prognosis with high expression of TRAIL and interferon related genes.
|
20953137 |
2010 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL.
|
19749795 |
2009 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Flavopiridol pretreatment synergized TRAIL-induced apoptosis in human myeloma and breast cancer cells.
|
17187253 |
2007 |
Multiple Myeloma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death.
|
17201122 |
2007 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRAIL has been proposed to mediate IFN-alpha2b apoptosis in myeloma.
|
17823654 |
2007 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
|
16026644 |
2005 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results highlight that MM T cells support OC formation and survival, possibly involving OPG/TRAIL interaction and unbalanced OC expression of TRAIL death and decoy receptors.
|
15308561 |
2004 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.
|
11830480 |
2002 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells.
|
11877293 |
2002 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Replication deficient Ad-p53 and human recombinant Apo2L/TRAIL were used.Myeloma cells with mutated/w.t. p53 and varying expression of bcl-2 were used to test the effect of Ad-p53, Apo2L/TRAIL, or both, on apoptosis, measured by annexin V.
|
11495702 |
2001 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These results warrant further clinical studies with IFNs and Apo2L in MM.
|
11568006 |
2001 |
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that myeloma cell expression of death effector receptors for TRAIL is insufficient to confer sensitivity to TRAIL-induced apoptosis but that in a significant minority of patients, irrespective of prior therapy, tumour cells are sensitive to TRAIL.
|
11587225 |
2001 |
Multiple Myeloma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we provide first time evidence that similar to Fas, TRAIL-induced apoptosis is not blocked by bcl-2 in MM cell lines.
|
10557057 |
1999 |