TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease BEFREE (1) We discuss how loss of TRAIL mediated apoptosis occurred in thyroid cancer cells and how different strategies can be used to restore apoptosis in resistant cancer cells; (2) We provide detailed account of seemingly opposite roles of NOTCH signaling in thyroid cancers; (3) TGF/SMAD mediated signaling also needs detailed research because of context dependent role in thyroid cancer. 29243843 2018
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease BEFREE Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis. 20926535 2011
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease BEFREE Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation. 19802013 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 GeneticVariation disease LHGDN These data indicate that nitric oxide-mediated S-nitrosylation of GAPDH and subsequent nuclear translocation of GAPDH might function as a mediator of TRAIL-induced cell death in thyroid cancer cells. 17540725 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease BEFREE In this study we explored the involvement of GAPDH in TRAIL-mediated thyroid cancer cell death. 17540725 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease LHGDN Our study demonstrated that IFNgamma combined with TRAIL can trigger apoptosis in vitro in several resistant thyroid tumor cell lines, such as thyroid anaplastic carcinoma cells (ARO cells), while either agent alone exerts only a minimal effect. 14647456 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.060 Biomarker disease BEFREE Our observations indicate that TRAIL effectively kills carcinomas that originate from the follicular epithelium of the thyroid gland, by inducing caspase-mediated apoptosis, and may provide a potentially potent therapeutic reagent against thyroid cancer. 10945619 2000