TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival. 31319548 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Apart from genetic changes in DR4-Ser424, we further classified various cancer cell lines originated from stomach, colon, lung, and glioblastoma according to their sensitivity to and receptor preference upon TRAIL death signaling and generated TRAIL-tolerant persister-derived DLD-1<sup>PER</sup> cells. 30987996 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Analyses of apoptotic signaling events revealed that pinoresinol enhanced the formation of TRAIL-mediated death-inducing signaling complex (DISC) and complete processing of procaspase-8 within the DISC in glioblastoma cells, in which caspase-8 was inactivated. 31534206 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE This combinational therapy through PEI-PLL-transfected mesenchymal stem cells can provide cost-effective, low immunogenic, and tumor-targeted delivery of suicideal genes (HSV-TK and TRAIL) for promising glioblastoma treatment. 30223091 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Taken together, this study provides evidence for the further development of metal-based anticancer agents and chemosensitizers of TRAIL for the treatment of human glioblastoma cancer cells. 29963768 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells. 29777390 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. 30385739 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Altogether, our findings show that H5CmTERT-Ad/TRAIL can promote dispersion of an oncolytic adenovirus through robust induction of apoptosis in a highly TRAIL-resistant glioblastoma. 29362367 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Taken together, our results identify the novel C27OAs as TRAIL sensitizers targeting the upstream DISC assembly of DR5, and provide a rationale for further development of C27OAs for facilitating TRAIL-based chemotherapy in glioblastoma patients. 30359578 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Identification of miRNA-7 by genome-wide analysis as a critical sensitizer for TRAIL-induced apoptosis in glioblastoma cells. 28459998 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE In conclusion, our data demonstrate that miR-133a promotes TRAIL resistance in glioblastoma by suppressing DR5 expression and activating NF-κB signaling. 28918048 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE In this study, we developed for the first time a novel vector CRAd5/11-D24.TRAIL/arresten by the following strategies: (1) modify CRAd5-D24 with Ad5/11 chimeric fiber to improve its infection efficiency for glioblastoma; and (2) insert two transgene expression cassettes into the E3 region and the region between the fiber and E4, respectively, for an enhanced therapeutic effect. 22136065 2012
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Our data suggest that therapy with TRAIL, either as monotherapy or in combination with demethylating agents, is not effective in treating glioblastoma because SCGs are not targeted by such treatment. 19214542 2009
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Moreover, lovastatin sensitized glioblastoma cells to TRAIL, suggesting a new strategy to treat glioblastoma. 17928957 2008
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Moreover, shWTE5 significantly enhanced apoptosis induced by chemotherapeutic agents, doxorubicin (DOX) and etoposide (ETP), or by death ligand TRAIL in all of the four solid tumor cells examined (HT-1080, LU99B, TYK and A172). 18292948 2008
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Weak expression of DR5 in primary glioma might limit the therapeutic application of Apo2L/TRAIL in human glioblastoma patients. 17595512 2007