Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Biomarker disease BEFREE The proapoptotic molecule TNF-related apoptosis-inducing ligand (TRAIL) has earned attention because of its ability to induce apoptosis in liver cancer cells without damaging normal liver cells. 25123818 2015
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Biomarker disease BEFREE TRAIL-secreting mesenchymal stem cells promote apoptosis in heat-shock-treated liver cancer cells and inhibit tumor growth in nude mice. 24451114 2014
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Biomarker disease BEFREE Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-known apoptosis inducer, we have previously demonstrated that acidic extracellular pH (pHe) switches TRAIL-induced apoptosis to regulated necrosis (or necroptosis) in human HT29 colon and HepG2 liver cancer cells. 22814620 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Biomarker disease BEFREE To establish the combined anti-tumor therapeutic effect of endostatin and soluble TRAIL (sTRAIL), we performed intra-tumoral human endostatin and sTRAIL gene transfer using plasmid pVAX1 as a vector in a nude mouse model of human liver cancer. 19223770 2009
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Therapeutic disease CTD_human Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. 18980244 2009
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 AlteredExpression disease BEFREE Transduction of human SMMC-7721 liver cancer cells with AAV-ISN-T led to higher levels of TRAIL(95-281) protein expression in the cell culture media and produced more apoptosis of the cells in vitro than those with AAV-IFN-T, AAV-HGH-T, and AAV-Alb-T. 16317690 2005
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 AlteredExpression disease BEFREE To observe the anti-liver cancer activity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene and its bystander effects on hepatocellular carcinoma (HCC) cell line SMMC7721. 14991932 2004
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.370 Biomarker disease BEFREE We demonstrated that our oncolytic vector (Ad5/35.IR-E1A/TRAIL) induced apoptosis in human tumor cell lines derived from colorectal, lung, prostate, and liver cancer. 15093180 2004