TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE This study demonstrated that pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 in ovarian cancer are associated with poor prognosis and low survival ratio of the patients. 27780136 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE Epigenetic and expression analysis of TRAIL-R2 and BCL2: on the TRAIL to knowledge of apoptosis in ovarian tumors. 24190693 2014
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 GeneticVariation disease BEFREE Considering a multiple-testing-corrected significance threshold of P < 2.5 × 10(-5), only one other variant, the TNFSF10 SNP rs6785617, was associated significantly with a risk of ovarian cancer (low malignant potential tumors OR, 0.85; 95% CI, 0.79-0.91; P = 0.00002). 24272484 2014
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE GT-oligo was found to induce transcript expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR-4 and DR-5, which are generally silenced in ovarian cancer cells, rendering them insensitive to TRAIL. 23634944 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Therapeutic disease CTD_human TLR4 activates NF-κB in human ovarian granulosa tumor cells. 21616060 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE Our findings indicate that c-FLIP(L) regulates sensitivity of OC to TRAIL-mediated apoptosis and offers possible therapeutical implications for OC in the future. 20227749 2010
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs. 15262127 2004
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 AlteredExpression disease LHGDN Using expression microarrays, we recently found that high expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene is associated with prolonged survival in advanced ovarian cancer. 12576447 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.380 Biomarker disease BEFREE Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. 12365003 2002