|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo results revealed that IQGAP1 promoted tumor growth and metastasis.
|
31101875 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of IQGAP1 or transfection of dominant-negative IQGAP1 impeded tumor cell proliferation and migration as well as PI3K/Akt signaling induced by MTA1.
|
29125886 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To the best of our knowledge, the present study is the first to report that <i>Clock</i>, acting through the regulation of the scaffolding protein IQGAP1, regulates the downstream expression of E-cadherin, thereby affecting tumor cell structure and motility.
|
29731875 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, downregulation of IQGAP1 suppressed tumor growth and EMT in SW579 tumor xenografts through the Wnt/β-catenin pathway in vivo.
|
28352188 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status.
|
28098764 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results revealed that IQGAP1 and CDC42 are frequently elevated in glioma tissues compared with their noncancerous counterparts, and a high expression of IQGAP1 and CDC42 correlates with tumor grades and poor overall survival of glioma patients.
|
28035419 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While the SUMOylation site mutation at K1445 of IQGAP1 greatly reduces CRC cell proliferation, migration ability and tumor growth of CRC-xenograft mice by suppressing phosphorylation of ERK, MEK and AKT.
|
28987385 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research of tumors.
|
28259970 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IQGAP1 has been suggested to be an oncogene, while IQGAP2 is considered a tumor-suppressor gene.
|
27488117 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lower IQGAP1 protein expression associated with higher tumor grade and decreased patient survival.
|
26078295 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, by using RNA interference (RNAi) technology we successfully silenced IQGAP1 gene in two ESCC cell lines, EC9706 and KYSE150, and for the first time found that suppressing IQGAP1 expression not only obviously reduced the tumor cell growth, migration and invasion in vitro but also markedly inhibited the tumor growth, invasion, lymph node and lung metastasis in xenograft mice.
|
24800852 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Survival analysis revealed that patients with either IQGAP1+ or IQGAP2- tumors had significantly reduced disease-free survival (p<0.001 and 0.006 respectively) and overall survival (p<0.001 for both).
|
24998570 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our studies demonstrate that IQGAP1 in the tumor microenvironment suppresses TβRII and TGF-β dependent myofibroblastic differentiation to constrain tumor growth.
|
23454766 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, overexpression of IQGAP1 was shown to be associated with the grades of tumor differentiation (P<0.05).
|
24103286 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.
|
23603816 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found IQGAP1 copy number (CN) gain ≥ 3 in 1 of 30 (3%), 24 of 74 (32%), 44 of 107 (41%), 8 of 16 (50%), and 27 of 41 (66%) of benign thyroid tumor, follicular variant papillary thyroid cancer (FVPTC), follicular thyroid cancer (FTC), tall cell papillary thyroid cancer (PTC), and anaplastic thyroid cancer, respectively, in the increasing order of invasiveness of these tumors.
|
20959410 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.
|
19433088 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings support the hypothesis that IQGAP1 promotes tumor progression and identify IQGAP1 as a potential therapeutic strategy for ovarian cancer and some other tumors with over-expression of the IQGAP1 gene.
|
19036171 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with these in vitro observations, immortalized MCF-7 cells overexpressing IQGAP1 form invasive tumors in immunocompromised mice, whereas tumors derived from MCF-7 cells with stable knockdown of IQGAP1 are smaller and less invasive.
|
17981797 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Receptor autoradiography was performed on slices from normal adrenals and tumour tissue by incubation with 125I-Sar1, Ile8-Ang II with and without pretreatment with cold Ang II or with the selective type 1 receptor antagonist losartan.
|
11380493 |
2001 |