|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In this study, the expression of the neuropilin-1 receptor in both pancreatic and prostate cancer stem cells was identified and targeted with a stimuli-responsive, polymeric nanocarrier to deliver a stemness inhibitor (napabucasin) to cancer stem cells.
|
29304437 |
2018 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
BEFREE |
This study identifies NRP1 for the first time as a novel androgen-suppressed gene upregulated during the adaptive response of prostate tumors to ATTs and a prognostic biomarker of clinical metastasis and lethal PCa.
|
28092670 |
2017 |
|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our research indicated CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment and this effect may relate with regulation of NRP1 and Noggin expression.
|
25338524 |
2015 |
|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Knockdown and overexpression of MAOA in human PCa cell lines indicated that MAOA induces EMT through activation of VEGF and its coreceptor neuropilin-1.
|
24865426 |
2014 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
BEFREE |
Neuropilin-1, p-NF-κB p65 and VEGF are predictors for the overall survival of Chinese men with PC.
|
24066029 |
2013 |
|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Importantly, NRP1 overexpression and c-MET activation were positively associated with progression and bone metastasis in human PCa specimens and xenograft tissues.
|
20085644 |
2010 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Prostate cancer cells expressed the mRNA for VEGF receptor (VEGFR) neuropilin-1 but not the VEGFRs Flt-1 or KDR.
|
16322239 |
2005 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
BEFREE |
AG490 (JAK2 specific) induced apoptosis in DU145 but not in NRP-154 prostate cancer lines, whereas piceatannol (JAK1 specific) induced apoptosis in NRP-154 but not in DU145 cells.
|
14749471 |
2004 |
|
Malignant neoplasm of pancreas
|
0.340 |
Biomarker
|
disease |
BEFREE |
The present results indicate that NRP-1 is negatively regulated by miR-141 and the miR-141/NRP-1 axis may serve as potentially valuable biomarkers and therapeutic targets for pancreatic cancer.
|
31572065 |
2019 |
|
Pancreatic Neoplasm
|
0.340 |
Biomarker
|
disease |
BEFREE |
Molecular MRI with protein nanocages was enabled to detect neuropilin-1-positive cells and to produce strong signal enhancement of spontaneous pancreatic tumors in KPC genetically engineered mouse models.
|
29107217 |
2018 |
|
Malignant neoplasm of pancreas
|
0.340 |
Biomarker
|
disease |
BEFREE |
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.
|
30027561 |
2018 |
|
Malignant neoplasm of pancreas
|
0.340 |
Biomarker
|
disease |
BEFREE |
These results indicate that ZIP4-mediated pancreatic cancer growth might involve angiogenesis, invasion and metastasis pathways, and NRP-1, VEGF and MMPs are important intermediate molecules in transducing the ZIP4 initiated signal cascades in pancreatic cancer.
|
20023433 |
2010 |
|
Pancreatic Neoplasm
|
0.340 |
Biomarker
|
disease |
LHGDN |
Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion.
|
17726369 |
2007 |
|
Pancreatic Neoplasm
|
0.340 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.
|
15956974 |
2005 |
|
Pancreatic Neoplasm
|
0.340 |
Biomarker
|
disease |
CTD_human |
Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.
|
15956974 |
2005 |
|
Malignant neoplasm of pancreas
|
0.340 |
Biomarker
|
disease |
CTD_human |
Chemosensitivity to gemcitabine or 5-fluorouracil (5-FU) was assessed by MTT assay in pancreatic cancer cells following NRP-1 overexpression or siRNA-induced downregulation of NRP-1.
|
15956974 |
2005 |
|
Malignant neoplasm of pancreas
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Thus, NRP-1 may play distinct growth regulatory roles in different tumor types, and altering NRP-1 expression or function may be a means of influencing the growth of pancreatic cancers.
|
15867361 |
2005 |
|
Pancreatic Neoplasm
|
0.340 |
Biomarker
|
disease |
LHGDN |
Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells.
|
14760080 |
2004 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
This study identifies NRP1 for the first time as a novel androgen-suppressed gene upregulated during the adaptive response of prostate tumors to ATTs and a prognostic biomarker of clinical metastasis and lethal PCa.
|
28092670 |
2017 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Prostatic Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
We have examined 42 primary sporadic prostate tumors at different clinical stages, together with 3 prostate cancer cell lines (DU145, PC3 and LNCaP), for expression of VEGF and the gene encoding the recently identified VEGF165 isoform-specific receptor neuropilin-1, by using a quantitative reverse transcription (RT)-PCR method.
|
10754495 |
2000 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Liver diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Blood gene expression markers to detect and distinguish target organ toxicity.
|
19784758 |
2010 |