|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The signal intensities of the T2-weighted images of the tumour tissues of each group as well as microscopic observations by Prussian blue staining indicated that the binding ability of this molecular probe to U87 glioma (HGG) with high NRP-1 expression was significantly greater than that of CHG-5 glioma (LGG) with low NRP-1 expression (P < 0.01).
|
31705924 |
2020 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We find that NRP1 expression is correlated with poor prognosis, glioma grade, and associates with the mesenchymal GB subtype.
|
30479695 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with Nrp1-deficient microglia and wild-type peripheral macrophages showed resistance to glioma development and had higher microglial infiltrate than mice with wild-type GAMs.
|
29097606 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo.
|
29982104 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The differentially expressed proteins were annotated using Gene Ontology, and neuropilin-1 (NRP1) was identified as the putative GDNF receptor in glioma.
|
29088765 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that NRP-1/GIPC1 pathway plays a vital role in glioma progression, and it is a potential important target for multi-gene combined therapeutics.
|
27481513 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, glioma survival times in mice with Nrp1-deficient GAMs were significantly longer.
|
26755653 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we examined the expression of NRP-1 in human glioma cell lines using Western blotting, and cell cycle distribution and proliferation by transfection of the U373 cell line with NRP-1 short interference RNA (siRNA).
|
21842123 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, knockdown of NRP1 or p130(Cas) or expression of either NRP1ΔC or a non-tyrosine-phosphorylatable substrate domain mutant protein (p130(Cas15F)) was sufficient to inhibit growth factor-mediated migration of glioma and endothelial cells.
|
21245381 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, increased phosphorylation of c-Met correlated with glioma progression in human glioma biopsies in which NRP1 is upregulated and in U87MG NRP1-overexpressing tumors.
|
17369861 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These results suggest that NRP1 overexpression, rather than VEGF-A or VEGFR, contributes to tumor progression and has clinical significance for glioma.
|
15160992 |
2004 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that NRP1 overexpression, rather than VEGF-A or VEGFR, contributes to tumor progression and has clinical significance for glioma.
|
15160992 |
2004 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins.
|
12730958 |
2003 |