|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
CTD_human |
Our results indicate that WISP1 present within the tumor microenvironment stimulates melanoma invasion and metastasis by promoting an EMT-like process.
|
30723155 |
2019 |
|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
BEFREE |
Metastasis assays revealed that <i>WISP1</i> knockout represses tumor metastasis of B16F10 and YUMM1.7 melanoma cells in both C57BL/6Ncrl and NOD-scid IL2Rγ<sup>null</sup> (NSG) mice.
|
30723155 |
2019 |
|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
BEFREE |
<b>Background</b>: WNT1-Inducible Signaling Pathway Protein 1 (WISP1) is implicated in prostate cancer growth and metastasis and the regulation of inflammation in diverse benign diseases.
|
31069142 |
2019 |
|
Neoplasm Metastasis
|
0.370 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, higher WISP1 expression in tumors from cancer patients correlates with faster progression to metastatic disease and poor prognosis.
|
31294477 |
2019 |
|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
BEFREE |
We also identified Wnt-induced secreted protein-1 (WISP-1) as a key downstream secretory mediator of Notch1 signaling to execute the influential role of MSC-DF on melanoma metastasis.
|
27813493 |
2016 |
|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
BEFREE |
WISP1 is a potential biomarker to predict the presence of LN metastases.
|
26391330 |
2016 |
|
Neoplasm Metastasis
|
0.370 |
Biomarker
|
phenotype |
BEFREE |
Therefore, WISP-1 could serve as therapeutic target to prevent metastasis and lymphangiogenesis in OSCC.
|
26824419 |
2016 |
|
Neoplasm Metastasis
|
0.370 |
AlteredExpression
|
phenotype |
BEFREE |
WISP-1 transcripts were found in lower levels in node-positive tumors compared with node-negative tumors (P < .05); were lower in patients with a moderate (P = .01) and poor Nottingham Prognostic Index prognosis (P < .05) compared with good prognostic groups; were of significantly lower level in grade 3 differentiated tumors (P < .05) compared with grade 1; and were of lower levels in patients who developed metastasis and died from breast cancer-related causes (P < .05 in both comparisons).
|
17406949 |
2007 |
|
Liver Cirrhosis, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Wnt-induced secreted protein 1/CCN4 in liver fibrosis both in vitro and in vivo.
|
24600972 |
2014 |
|
Hyperoxia
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
|
23481549 |
2013 |
|
Airway Remodeling
|
0.200 |
Therapeutic
|
phenotype |
RGD |
A role for WNT1-inducible signaling protein-1 in airway remodeling in a rat asthma model.
|
23845395 |
2013 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Public data portals, including Oncomine, The Cancer Genome Atlas database, Coexpedia, and Kaplan-Meier plotter, were analyzed for the expression and clinical significance of WISP1 mRNA levels in GC.
|
31636474 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The consequences of WISP1 expression on cancer immunotherapy remains to be addressed.
|
31069142 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
WISP1 also promoted cancer cell tumorigenicity and growth in mice implanted with Hep-2 cells.
|
30805937 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, higher WISP1 expression in tumors from cancer patients correlates with faster progression to metastatic disease and poor prognosis.
|
31294477 |
2019 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients carrying the WISP1 rs2929973 GG + TT variant were almost twice as likely as those carrying the GT genotype to have estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors, while those with the WISP1 rs62514004 AG + GG genetic variants were around twice as likely as those with the AA genotype to have HER2-positive tumors.
|
31689877 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Specifically, WISP1 directly binds to type I collagen to promote its linearization in vitro (in the absence of cells) and in vivo in tumors.
|
31294477 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<b>Methods</b>: Publicly available RNA-seq datasets were used to evaluate the prognostic value of WISP1 gene expression and its association with tumor-infiltrating lymphocytes, inflamed tumor microenvironment, and anti-PD-1 ICB response.
|
31069142 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Experiments testing EMT gene activation and inhibition with recombinant WISP1 or kinase inhibitors in B16F10 and YUMM1.7 cells suggested that WISP1 activates AKT Ser/Thr kinase and that MEK/ERK signaling pathways shift melanoma cells from proliferation to invasion.
|
30723155 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, WISP1 silencing suppressed TEC migration and invasion, whereas LiCI treatment promoted TEC migration and invasion.
|
30556898 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Circ_KATNAL1 regulates prostate cancer cell growth and invasion through miR-145-3p/WISP1 pathway.
|
31800303 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Consequently, WISP1-induced type I collagen linearization facilitates tumor cell invasion and promotes spontaneous breast cancer metastasis, without significantly affecting gene expression.
|
31294477 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The consequences of WISP1 expression on cancer immunotherapy remains to be addressed.
|
31069142 |
2019 |