PROM1, prominin 1, 8842

N. diseases: 477; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases
0.010 Biomarker group BEFREE This indicates that CD34‑CD133+ cells are more pluripotent compared to the CD34+CD133+ EPC subset, which may have important consequences for the therapy of vascular diseases. 31746407 2020
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 AlteredExpression disease BEFREE Therefore, we investigated the effect of Alu-mediated p21 transcriptional regulator (APTR), fibroblast growth factor-inducible 14 (Fn14) and CD133 expressions on liver fibrosis in Indonesian BA patients. 31549181 2020
CUI: C0346957
Disease: Disseminated Malignant Neoplasm
Disseminated Malignant Neoplasm
0.010 AlteredExpression phenotype BEFREE Immunohistochemical analysis showed the strong expression of CD133 in metastatic cancer. 31646784 2020
CUI: C0545069
Disease: Intermediate cell carcinoma
Intermediate cell carcinoma
0.010 Biomarker disease BEFREE In HCC-INT, the CD133 positive rate in the INT component (83.3%) was significantly higher than the HCC component (8.3%) (P=0.001). 31661725 2020
CUI: C1321865
Disease: Juvenile astrocytoma
Juvenile astrocytoma
0.010 Biomarker disease BEFREE Clinical significance of CD133 and Nestin in astrocytic tumor: The correlation with pathological grade and survival. 31677196 2020
CUI: C1332183
Disease: Adult Astrocytic Tumor
Adult Astrocytic Tumor
0.010 Biomarker disease BEFREE Clinical significance of CD133 and Nestin in astrocytic tumor: The correlation with pathological grade and survival. 31677196 2020
CUI: C1334557
Disease: Malignant Adult Brain Neoplasm
Malignant Adult Brain Neoplasm
0.010 Biomarker disease BEFREE CD133 has reproducibly been shown to correlate with disease progression, recurrence, and poor overall survivorship in the malignant adult brain tumor, glioblastoma (GBM). 31695152 2020
CUI: C1623038
Disease: Cirrhosis
Cirrhosis
0.010 AlteredExpression disease BEFREE Intriguingly, CD133 expression was strongly related with the survival of BA patients (p = 0.0061), but not with age at Kasai procedure (p = 0.36) and the presence of cirrhosis (p = 0.77). 31549181 2020
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis
0.010 Biomarker disease BEFREE Genotyping of >2000 colonies from CD133+HSC and progenitors from PMF patients confirmed the complex genetic heterogeneity within the neoplastic population. 29907810 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 Biomarker disease BEFREE We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. CD34+CD133+KDR+ conventional EPC. 31017736 2019
CUI: C0003962
Disease: Ascites
Ascites
0.010 Biomarker phenotype BEFREE Glycosylation of ascites-derived exosomal CD133: a potential prognostic biomarker in patients with advanced pancreatic cancer. 30805710 2019
CUI: C0004509
Disease: Azoospermia
Azoospermia
0.010 Biomarker disease BEFREE The aim of this study was to investigate the relationship of the CD133 and CD24 genes with spermatogenesis defects and examine them as a candidate a useful biomarker for azoospermia men. 31054360 2019
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease
0.010 Biomarker disease BEFREE Levels of circulating CD34(+)/VEGFR2(+) and CD133(+)/VEGFR2(+) were significantly higher in the newly diagnosed untreated patients with HL compared to the patients with HL in remission (P = 0.03 and P = 0.005, respectively), in the patients in remission compared to the patients with diabetes (P = 0.011 and P < 0.001, respectively), and in the patients in remission compared to the healthy individuals (P = 0.08 and P = 0.003, respectively). 30549248 2019
CUI: C0028960
Disease: Oligospermia
Oligospermia
0.010 Biomarker disease BEFREE Immunohistochemical analysis of CD133 revealed moderate, partial staining in the HS group, compared to substantial, wide-spread staining in the OA group. 31054360 2019
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.010 Biomarker disease BEFREE Our study thus showed that GAS5 acts as a molecular switch for regulating quiescence and growth arrest in CD133+ population, that is responsible for aggressive biology of pancreatic tumors. 31740660 2019
CUI: C0031099
Disease: Periodontitis
Periodontitis
0.010 AlteredExpression disease BEFREE Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (<i>p</i>-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, <i>p</i>-trend = 0.003), probing depth (PD, <i>p</i>-trend = 0.007), and bleeding sites (bleeding on probing (BOP), <i>p</i>-trend < 0.001) as an extent measure of periodontitis. 31817862 2019
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.010 Biomarker group BEFREE The CD44 <sup>(+)</sup>, CD133 <sup>(+)</sup> cell subpopulations were isolated from human prostate tumors which exhibit stem-like properties showing therapeutic-resistance, capacity of self-renewal, and exact recapitulation of the original tumor <i>in vivo</i>. 30728896 2019
CUI: C0035067
Disease: Renal Artery Stenosis
Renal Artery Stenosis
0.010 Biomarker disease BEFREE CD24+/CD133+ STCs were isolated from pig kidneys after 10-weeks of RAS or sham (<i>n</i> = 3 each) and their gene cargo analyzed using high-throughput mRNAseq. 31614781 2019
CUI: C0039585
Disease: Androgen-Insensitivity Syndrome
Androgen-Insensitivity Syndrome
0.010 Biomarker disease BEFREE To understand the mechanisms of augmented arteriogenesis and angiogenesis in acute ischemic stroke (AIS) patients, we investigated whether circulating stem cells (CD133+), early endothelial progenitor cells (CD133+/VEGFR2+), and endothelial cells (ECs; CD34¯/CD133¯/VEGFR2+) were increasingly mobilized during AIS, and whether there were correlations between EPC levels, growth factor levels and inflammatory parameters. 30706812 2019
CUI: C0079588
Disease: Ichthyosis, X-Linked
Ichthyosis, X-Linked
0.010 Biomarker disease BEFREE In conclusion, ALDH1, CD44, and CD133 are not likely to be useful markers of CSCs in STS. 30999901 2019
Polycystic Kidney, Autosomal Dominant
0.010 AlteredExpression disease BEFREE Among these, CD133 was upregulated in exosomes from autosomal dominant polycystic kidney disease and validated by ELISA. 31018934 2019
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma
0.010 Biomarker disease BEFREE Levels of circulating CD34(+)/VEGFR2(+) and CD133(+)/VEGFR2(+) were significantly higher in the newly diagnosed untreated patients with HL compared to the patients with HL in remission (P = 0.03 and P = 0.005, respectively), in the patients in remission compared to the patients with diabetes (P = 0.011 and P < 0.001, respectively), and in the patients in remission compared to the healthy individuals (P = 0.08 and P = 0.003, respectively). 30549248 2019
CUI: C0220613
Disease: Adult Soft Tissue Sarcoma
Adult Soft Tissue Sarcoma
0.010 Biomarker disease BEFREE This study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macrophage marker CD68 in soft tissue sarcomas (STS) before and after 4 cycles of chemotherapy with doxorubicin and ifosfamide in 31 patients with high-grade soft tissue sarcoma in a prospective clinical trial. 30999901 2019
CUI: C0220644
Disease: Childhood Hodgkin Lymphoma
Childhood Hodgkin Lymphoma
0.010 Biomarker disease BEFREE Levels of circulating CD34(+)/VEGFR2(+) and CD133(+)/VEGFR2(+) were significantly higher in the newly diagnosed untreated patients with HL compared to the patients with HL in remission (P = 0.03 and P = 0.005, respectively), in the patients in remission compared to the patients with diabetes (P = 0.011 and P < 0.001, respectively), and in the patients in remission compared to the healthy individuals (P = 0.08 and P = 0.003, respectively). 30549248 2019
CUI: C0220645
Disease: Childhood Soft Tissue Sarcoma
Childhood Soft Tissue Sarcoma
0.010 Biomarker disease BEFREE This study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macrophage marker CD68 in soft tissue sarcomas (STS) before and after 4 cycles of chemotherapy with doxorubicin and ifosfamide in 31 patients with high-grade soft tissue sarcoma in a prospective clinical trial. 30999901 2019