Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD133-positive cancer stem cells in colon cancer are resistant to conventional chemotherapy.
|
23245395 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD66c was absent in CD133-positive cells that were isolated from normal colon, whereas its expression was brightest (CD66c(bright) ) in CD133-positive cells from colon cancer samples.
|
23027178 |
2013 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer.
|
20379837 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To elucidate the role of CD133 expression in chemoresistance, we silenced the CD133 expression in a colon cancer cell line and determined its effect on the biological characteristics downstream.
|
26002465 |
2015 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using three independent primary spheroidal colon cancer cultures that expressed a Wnt reporter construct we observed high Wnt activity was associated with the cell surface markers CD133, CD166, and CD29, but not CD24 and CD44, while the original study found all five markers were correlated with high Wnt activity (Figure 2F; Vermeulen et al., 2010).
|
31215867 |
2019 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases.
|
25625240 |
2015 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence.
|
22231565 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Care must be taken if CD133 is used as the only marker of cancer stem cells in colon cancer, especially in established cell lines.
|
20023382 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Different results were also obtained using the two antibodies to analyze the expression of the CD133 molecule in human colon cancers.
|
20333645 |
2010 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Various differentially expressed genes were identified and the most relevant transcripts found to be over-expressed in CD133(+) cells were evaluated by quantitative RT-PCR in the CD133(+) fractions isolated from several CC cell lines.
|
21826669 |
2011 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
On the whole, our data indicated that patients with colon cancer with CD133-negative expression had a reduced disease-free survival.
|
29328371 |
2018 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
According to the cancer stem cell (CSC) model, higher CD133 expression in tumor tissue is associated with metastasis and poor prognosis in colon cancer.
|
23577199 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the human colon cancer cell line, SW620, contains both CD133(+) and CD133(-) phenotypes, and the CD133(+) phenotype has characteristics consistent with those of cancer stem cells.
|
20587144 |
2010 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study illustrates a novel target to eliminate the tumorigenic CD133(+) cell population in colon cancer and provides another rationale for the development of specific ATR-inhibitors.
|
21308861 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Automated FISH analysis was performed on 13 different colon cancer samples that had been stained for CD133; each sample was scored for MYC, ZNF217 and Chromosome 6 in CD133 positive and negative glands.
|
21656271 |
2011 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Studies have shown that the expression of CD133, leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5), and ATP binding cassette (ABC)G2 proteins is associated with malignancy and poor prognosis in colon cancer.
|
23619912 |
2013 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using the CD133 siRNA knockdown strategy and non-differentiated human colon cancer Caco-2 cells that constitutively over-expressed CD133, we provide for the first time direct evidence for a role of CD133 in the intracellular accumulation of fluorescently labeled extracellular compounds.
|
21966538 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD133+ colon cancer cells (LoVo) were infected with the lentiviral vector carrying CD133 gRNA and purified cell by culturing single cell colonies.
|
31393941 |
2019 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that RAC3 overexpression was mainly associated to CD133+ side-population of colon cancer cells and also to early and advanced stages of colon cancer, involving increased expression of mesenchymal and stem markers.
|
29464039 |
2018 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
We isolated CD133+ and CD133- subpopulations from the colon cancer tissues and cultured cells.
|
20711432 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Assessment of neutralizing interleukin-4 effect on CD133 gene expression in colon cancer cell line.
|
28578295 |
2017 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CD133 and CD44 were regarded as markers of CCSCs and they were found to be co-expressed in the HCT116 colon cancer cell line.
|
27600678 |
2016 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, p-STAT3 may participate in the progression of the early stage of colon cancer through the up-regulation of CD133, which in turn induces survivin expression.
|
29432737 |
2018 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery.
|
20332776 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CD133 expression was evaluated by flow cytometry in three colon cancer cell lines (HCT116, Lovo and DLD1).
|
27387378 |
2019 |