PROM1, prominin 1, 8842

N. diseases: 477; N. variants: 33
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE In this study, by FACS analysis we determined the percentage of CD133 positive cells in three primary cultured cell lines established from glioblastoma patients 10.2%, 69.7% and 27.5%, respectively. 17140455 2006
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE CD133-expressing tumour cells isolated from both human glioma xenografts and primary patient glioblastoma specimens preferentially activate the DNA damage checkpoint in response to radiation, and repair radiation-induced DNA damage more effectively than CD133-negative tumour cells. 17051156 2006
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Together, our data provide first evidence that CD133(+) CSC maintain only a subset of primary glioblastomas. 17483311 2007
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE We examined the microRNA profiles of Glioblastoma stem (CD133+) and non-stem (CD133-) cell populations and found up-regulation of several miRs in the CD133- cells, including miR-451, miR-486, and miR-425, some of which may be involved in regulation of brain differentiation. 18765229 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease LHGDN This study revealed for the first time that: a) serum deprivation enriched CD133 expression and demonstrated a direct co-expression between CD133 and drug resistant in GOS-3 cells and b) higher expression of CD133 and drug resistance were found in glioblastoma tissues in comparison to normal brain tissues. 18568776 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 PosttranslationalModification disease BEFREE Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. 18829568 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE This study revealed for the first time that: a) serum deprivation enriched CD133 expression and demonstrated a direct co-expression between CD133 and drug resistant in GOS-3 cells and b) higher expression of CD133 and drug resistance were found in glioblastoma tissues in comparison to normal brain tissues. 18568776 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE In this study, we isolated a small proportion of CD133+ GSCs from the human glioblastoma cell line U87 and found that these GSCs possessed multipotent differentiation potential and released high levels of VEGF as compared with CD133(-) tumour cells. 18523971 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease CTD_human Taken together, our results indicate that DNA hypomethylation is an important determinant of CD133 expression in glioblastomas, and this epigenetic event may be associated with the development of BTICs expressing CD133. 18679414 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease LHGDN Glioblastoma patients showed elevated levels of membrane particle-associated prominin-1/CD133, which decreased dramatically in the final stage of the disease. 18096722 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 PosttranslationalModification disease BEFREE Taken together, our results indicate that DNA hypomethylation is an important determinant of CD133 expression in glioblastomas, and this epigenetic event may be associated with the development of BTICs expressing CD133. 18679414 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 PosttranslationalModification disease LHGDN Taken together, our results indicate that DNA hypomethylation is an important determinant of CD133 expression in glioblastomas, and this epigenetic event may be associated with the development of BTICs expressing CD133. 18679414 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease CTD_human We find that, within individual cell lines of cultured colon cancers and glioblastomas, the promoter CpG island of CD133 is DNA methylated, primarily, in cells with absent or low expression of the marker protein, whereas lack of such methylation is evident in purely CD133+ cells. 18829568 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. 19468690 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE In addition, we identified the crossreactivity of CD133 and MDR1 in a surgical specimen of GBM. 19832037 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Growing CD133(+) cells sorted from three GB neurosphere cultures at 7% O(2) reduced their doubling time and increased the self-renewal potential as reflected by clonogenicity. 19372578 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE These data indicate that the mechanisms through which CD133+ TSCs respond to radiation are significantly different from those of the traditional glioblastoma in vitro model, established glioma cell lines. 19671863 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease CTD_human Glioblastoma formation from cell population depleted of Prominin1-expressing cells. 19718438 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE A CD133(+) U87 glioma cell population was isolated from parental U87 glioblastoma cells using magnetic cell sorting technology. 19326372 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE We hypothesized that CD133+ glioblastoma cells presenting stem-cell properties may express pro-vascular molecules allowing them to form blood vessels de novo. 20375132 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 AlteredExpression disease BEFREE To better understand the effect of this tumor on allergies and inflammation, we used CD133 mRNA expression as an indicator of tumor aggressiveness and systematically examined its relation to mRNA expression levels of 919 allergy- and inflammation-related genes in 142 glioblastoma tissue samples. 20308310 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Flow cytometry analysis showed the presence of CD133(-) subpopulations expressing these markers in glioma cell lines and in primary cultures from human glioblastoma (GBM) biopsies. 20460538 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. 19904829 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 Biomarker disease BEFREE Influence of Etoposide on anti-apoptotic and multidrug resistance-associated protein genes in CD133 positive U251 glioblastoma stem-like cells. 20388502 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.400 GeneticVariation disease BEFREE Because AC133 and 293C antibodies do not detect all CD133 variants in glioblastoma cells, alternate detection methods need to be utilized for complete analysis of CD133 expression and for accurately determining the relationship between CD133 and cancer stem-like cells. 20428792 2010