Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133 liver cancer cells were injected into mice, and the tissues were processed for histology. 31646784 2020
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE This data demonstrates that the complex involvement of TIPRL/LC3/CD133 in liver cancer aggressiveness can together or individually serve as potential biomarkers for the early detection of liver cancer. 31727942 2019
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. 31197130 2019
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE We observed that Cygb is significantly deregulated in human hepatocellular carcinoma (HCC) tissue and its decrease aggravates the growth of liver cancer stem cells (LCSCs) and increases the subpopulation of CD133(+) LCSCs. 30365183 2019
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Altogether, CD133-induced TM4SF5 expression and function were important for liver cancer sphere growth and may be a promising target to block metastasis. 30217560 2018
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Furthermore, we revealed that the expression of liver cancer stem cell marker CD133 was also significantly increased in the residual hepatocellular carcinoma cells after RFA treatment in vivo, and was positively correlated with LC3B protein expression. iRFA also promoted CD133 protein expression in Huh-7 and SMMC7721 cell lines in vitro. 29749472 2018
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Down-regulating Bmi-1 may inhibit the biological properties of CD133+ LCSC by blocking NF-κB signaling pathway, which lays a scientific foundation for the clinical treatment of liver cancer. 29843222 2018
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133. 28367990 2017
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Here, we found that oxidative stress increase CD133 expression in HCC and increased CD133 expression enhanced the capacity of the defense system against ROS, and thereby play a central role in resistance to liver cancer therapy. 28253902 2017
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE In the present study, we investigated the role of ELK3 in cancer cell invasion and metastasis in CD133+/CD44+ liver cancer stem cells (LCSCs). 27959451 2017
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL. 28281970 2016
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy. 26758620 2016
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Also, CXCR3-A suppressed the adhesion ability of CD133+ liver cancer cells that stimulated by CXCL9 for 24h. 26883105 2016
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133 is a specific surface marker for liver cancer stem cells (LCSCs), which is also considered as an important functional factor for tumorigenesis and overall survival in HCC. 26370320 2015
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Mir-152 inhibits cell proliferation and colony formation of CD133(+) liver cancer stem cells by targeting KIT. 25311946 2015
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 AlteredExpression disease BEFREE Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma. 25301737 2014
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells. 24556826 2014
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE In the present report we describe the differential DNA methylome of CD133-negative and CD133-expressing liver cancer cells. 24898317 2014
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells. 23438193 2013
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE Biology and clinical implications of CD133(+) liver cancer stem cells. 22999864 2013
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE In this study, we aimed to isolate and characterize a small population of CD133+ cells that existed in the HCC cell line SMMC-7721 by MACS and investigated the possible roles of 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, in inhibiting the properties of CD133+ sphere-forming cells (SFCs) derived from the HCC cell line SMMC-7721, namely liver cancer stem cells (LCSCs). 23970349 2013
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE The stem cell properties of CD133(+) SFCs were validated by the tumorsphere formation assay in vitro and the xenograft nude mouse model in vivo, and termed liver cancer stem cells (LCSCs). 24431896 2013
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133 silencing inhibits stemness properties and enhances chemoradiosensitivity in CD133-positive liver cancer stem cells. 23233126 2013
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma. 22079466 2012
Liver and Intrahepatic Biliary Tract Carcinoma
0.100 Biomarker disease BEFREE microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. 22025269 2012