In this study, the formation of caffeine/dapsone (CAF/DAP) cocrystals by scalable production methods, such as liquid-assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed cocrystal powder for pulmonary delivery.
The adsorption and release of two drugs 5FU (5-fluorouracil) and CAF (caffeine) into and from the ZIF-8 framework were simulated by the Gibbs-ensemble Monte Carlo approach employing two models for representing the sorbent: one without surface (ZIF-8P) and another with surface (ZIF-8S).
The athletes received anhydrous caffeine (CAF: 6 mg / kg body mass) or placebo (PLA) 60 minutes before a CrossFit workout with tasks that involved muscle strength, power, gymnastic movements, and metabolic conditioning.
Thereafter, during a 15 min simulated half-time period, players chewed either caffeine (CAF: 400 mg; 4.1 ± 0.5 mg·kg) or PL gum for five min before completing a second repeated sprint test (RSSA2).
Therefore, we sought to evaluate the effect of frequent caffeine-maltodextrin (CAF-MALT) mouth rinsing on mental fatigue induced by a prolonged cognitive task.
Twenty-four participants completed 4 counterbalanced experimental sessions, during which they performed MR with either placebo (PL), carbohydrate (CHO: 1.6 g/25 mL), guarana complex (GUAc: 0.4 g/25 mL) or caffeine (CAF: 67 mg/25 mL) before and twice during exercise.