Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3151465
Disease: PROTEIN Z DEFICIENCY
PROTEIN Z DEFICIENCY
0.300 Biomarker disease GENOMICS_ENGLAND R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation. 15638861 2005
CUI: C3151465
Disease: PROTEIN Z DEFICIENCY
PROTEIN Z DEFICIENCY
0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C0005890
Disease: Body Height
Body Height
0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement
0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0037290
Disease: Skin Pigmentation
Skin Pigmentation
0.100 GeneticVariation phenotype GWASCAT Identification of a novel locus associated with skin colour in African-admixed populations. 28300201 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.040 GeneticVariation group BEFREE We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64. 27683756 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.040 GeneticVariation group BEFREE Furthermore, a protective role in juvenile stroke was shown for a SNP of the vitamin K dependent protein Z (PZ Intron F G79A) which is linked with low PZ levels. 16155788 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.040 AlteredExpression group LHGDN A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. 14671240 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.040 AlteredExpression group LHGDN Protein Z in ischemic stroke and its etiologic subtypes. 12970515 2003
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.030 GeneticVariation disease BEFREE We identified the functional variant rs494860 in the protein Z (PROZ) gene as our strongest association with occurrence of cerebral infarction (odds ratio (OR) 0.49 (95% confidence interval 0.33-0.73), p = 5.2 × 10<sup>-4</sup>). 29746949 2018
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.030 GeneticVariation disease BEFREE Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults. 27683756 2017
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.030 GeneticVariation disease BEFREE We investigated a possible association of 2 common single nucleotide mutations in the PZ gene with the risk of cerebral ischemia. 14671240 2004
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell
0.010 GeneticVariation disease BEFREE As Protein Z and Endothelin-1 genetic polymorphisms may increase the thrombotic risk, the aim of the current work was to verify the possible impact of Protein Z (PROZ G79A) and Endothelin-1 (EDN1 G5665T) polymorphisms on the clinic-laboratory features of the SCD in a cohort of Egyptian pediatric patients. 28548215 2018
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions
0.010 GeneticVariation disease BEFREE We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64. 27683756 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 AlteredExpression group LHGDN Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis. 18180611 2008
CUI: C0034186
Disease: Pyelonephritis
Pyelonephritis
0.010 Biomarker disease LHGDN Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. 18828054 2008
CUI: C0042487
Disease: Venous Thrombosis
Venous Thrombosis
0.010 GeneticVariation phenotype LHGDN The G79A polymorphism of protein Z gene is an independent risk factor for cerebral venous thrombosis. 18677630 2008
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia
0.010 Biomarker phenotype LHGDN Preeclampsia is associated with low concentrations of protein Z. 17701666 2007
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.010 GeneticVariation disease LHGDN A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. 14671240 2004
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.010 Biomarker disease LHGDN [Protein Z: a new regulator of coagulation in arterial vessels?]. 15314579 2004
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.010 AlteredExpression disease LHGDN Decreased protein Z concentrations complicating the hypercoagulable state of Behçet's disease. 14507116 2003