|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, we developed ZT-12-037-01 (1a) as a specific STK19-targeted inhibitor and showed that it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo.
|
30712867 |
2019 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These are highly aggressive cancers with metastasis, and recent studies have shown the presence of mutations in RAC1, PPP6C and STK19 genes in melanoma patients.
|
30509087 |
2019 |
|
Malignant transformation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, we developed ZT-12-037-01 (1a) as a specific STK19-targeted inhibitor and showed that it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo.
|
30712867 |
2019 |
|
Cutaneous Melanoma
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Squamous cell carcinoma of skin
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Pigmented Basal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
|
26950094 |
2016 |
|
Carcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
|
26950094 |
2016 |
|
Membranous glomerulonephritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
|
21323541 |
2011 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
|
23263863 |
2013 |
|
Sarcoidosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.
|
26651848 |
2016 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Exudative age-related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
|
Geographic Atrophy
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
exudative macular degeneration
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
von Willebrand's factor (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.
|
30586737 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
|
20598377 |
2010 |