CCKBR, cholecystokinin B receptor, 887

N. diseases: 105; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.510 Biomarker phenotype BEFREE RVM microinjection of the CCK2 receptor agonist CCK-8 and intrathecal injection of the 5-HT2B receptor agonist BW723C86 both produced hyperalgesia in female rats after plantar incision, whereas the CCK2 receptor antagonist YM022, the 5-HT2B receptor antagonist RS127445, and the PKCγ inhibitor C37H65N9O13 decreased the rats' sensitivity to the same stimulus. 31308730 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.510 Biomarker phenotype RGD Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. 15647484 2005
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.510 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Also, there is some support for a role of the CCK system in the genetic pathomechanism of PD with particularly strong evidence for the CCK gene itself and the CCK-2R (CCKBR) gene. 22553078 2012
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Given the potential role of the central cholecystokinin receptor (CCKBR) (CT) polymorphism alleles 26 and 27 in PD, the present study attempted to discern if these alleles moderated panicogenic sensitivity to the CCKBR agonist, CCK-tetrapeptide (CCK-4), in healthy volunteers. 22414867 2012
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE We examined the promoter, exon, and exon-intron boundaries of the genes encoding CCK and its receptors (CCKAR and CCKBR) for variations in 187 patients with PD and 277 screened control individuals. 20023595 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE We therefore determined the allele and genotype frequencies of a single nucleotide polymorphism in the CCK gene (-36C>T) and one CT repeat polymorphism in the CCK-B-receptor gene in a German panic disorder sample (n = 115 for CCK gene polymorphism, n = 111 for CCK-B-receptor polymorphism) and compared them with gender and age matched controls. 15354400 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease LHGDN We therefore determined the allele and genotype frequencies of a single nucleotide polymorphism in the CCK gene (-36C>T) and one CT repeat polymorphism in the CCK-B-receptor gene in a German panic disorder sample (n = 115 for CCK gene polymorphism, n = 111 for CCK-B-receptor polymorphism) and compared them with gender and age matched controls. 15354400 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease BEFREE Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. 11515749 2001
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease BEFREE Recent association studies using persons with panic disorder described some association between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B-receptor and panic disorder. 11244486 2001
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE There was a significantly higher prevalence of the panic disorder-associated CCK-B receptor allele 7 in subjects with IEI (9/22 [40.9%]) compared with control subjects (2/22 [9.1%], P =.037). 11344357 2001
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease BEFREE Together with the negative reports on association analyses using other polymorphisms of the CCKBR gene and Japanese samples, the present results exclude a major genetic contribution of the CCKBR gene to susceptibilities to panic disorder and schizophrenia in Japanese cohorts. 11803530 2001
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Our genetic dissection of the CCK system thus far suggests that the CCK-B receptor gene variation may contribute to the neurobiology of panic disorder. 10395221 1999
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 Biomarker disease CTD_human The panic-inducing properties of pentagastrin are not specific for panic disorder patients, which might be indicative of a common neurobiological dysfunction in panic disorder and OCD at the level of CCK-B receptors. 8878350 1996
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.400 GeneticVariation disease BEFREE Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. 8837709 1996
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Thus, a potential therapeutic role for CCK-A antagonists in the treatment of ethanol abuse and for CCK-B antagonists in the treatment of cocaine abuse is proposed. 9922984 1998